105624-86-0
105624-86-0
Chemical Structure
5HPP-33
- CAS No.: 105624-86-0
- Formula:C20H21NO3
- Molecular Weight:323.39
IUPAC Name: 2-(2,6-diisopropylphenyl)-5-hydroxyisoindoline-1,3-dione
InChIKey: LAKWINYVWJPHQW-UHFFFAOYSA-N
SMILES: O=C1C2=CC=C(C=C2C(N1C3=C(C(C)C)C=CC=C3C(C)C)=O)O
Biological Activity: 5HPP-33 is an inhibitor for tubulin polymerization with IC50 of 8.1 μM. 5HPP-33 inhibits the proliferation of leukemia cell and multiple myeloma cells with IC50 of 1-10 μM, arrests the cell cycle at G2/M phase, and induces apoptosis[1][2].
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5HPP-33 | 5HPP-33 is an inhibitor for tubulin polymerization with IC50 of 8.1 μM. 5HPP-33 inhibits the proliferation of leukemia cell and multiple myeloma cells with IC50 of 1-10 μM, arrests the cell cycle at G2/M phase, and induces apoptosis. | |||||||||||||||||||||
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References
- [1]. Inatsuki S, et al. Tubulin-polymerization inhibitors derived from thalidomide. Bioorg Med Chem Lett. 2005 Jan 17;15(2):321-5. [Content Brief]
- [2]. Iguchi T, et al. 5HPP-33, a Novel Tubulin-Polymerization Inhibitor Derived from Thalidomide, Directly Inhibits Proliferation and Induces Apoptosis of Human Multiple Myeloma Cells[J]. Blood, 2005, 106(11): 1586.
Keywords
