34576-94-8
34576-94-8
Chemical Structure
BT2
- CAS No.: 34576-94-8
- Formula:C9H4Cl2O2S
- Molecular Weight:247.10
IUPAC Name: 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid
InChIKey: AAHPIJMQJAZYTM-UHFFFAOYSA-N
SMILES: O=C(O)C1=C(C2=CC=C(C=C2S1)Cl)Cl
Biological Activity: BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC)[1]. BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BT2 | 99.81% | BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 binding to BDK triggers helix movements in the N-terminal domain, resulting in the dissociation of BDK from the branched-chain α-ketoacid dehydrogenase complex (BCKDC). BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM. | ||||||||||||||||||||
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References
- [1]. Tso SC, et al. Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase. J Biol Chem. 2014 Jul 25;289(30):20583-93. [Content Brief]
- [2]. Friberg A, et al. Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J Med Chem. 2013 Jan 10;56(1):15-30. [Content Brief]
Keywords
