2. Signaling Pathways
  3. Apoptosis
  4. Bcl-2 Family
  5. Mcl-1 Isoform
  6. Mcl-1 Modulator

Mcl-1 Modulator

Mcl-1 Modulator (1):

Cat. No. Product Name Effect Purity
  • HY-15867
    Meayamycin B
    		Modulator
    Meayamycin B ((+)-Meayamycin B) is a potent SF3B1 inhibitor. Meayamycin B upregulates the proapoptotic Mcl-1S and downregulates Mcl-1L at the pre-mRNA splicing level. Meayamycin B does not regulate the alternative splicing of Bcl-x. Meayamycin B and ABT-737 (HY-50907) synergistically causes Apoptosis. Meayamycin B exhibits anticancer activity against non-small cell lung cancer.