2. Epigenetics Apoptosis
  3. SF3B1 Bcl-2 Family Apoptosis
  4. Meayamycin B

Meayamycin B ((+)-Meayamycin B) is a potent SF3B1 inhibitor. Meayamycin B upregulates the proapoptotic Mcl-1S and downregulates Mcl-1L at the pre-mRNA splicing level. Meayamycin B does not regulate the alternative splicing of Bcl-x. Meayamycin B and ABT-737 (HY-50907) synergistically causes Apoptosis. Meayamycin B exhibits anticancer activity against non-small cell lung cancer.

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Meayamycin B

Meayamycin B Chemical Structure

CAS No. : 1020210-12-1

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Meayamycin B Related Antibodies

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Description

Meayamycin B ((+)-Meayamycin B) is a potent SF3B1 inhibitor. Meayamycin B upregulates the proapoptotic Mcl-1S and downregulates Mcl-1L at the pre-mRNA splicing level. Meayamycin B does not regulate the alternative splicing of Bcl-x. Meayamycin B and ABT-737 (HY-50907) synergistically causes Apoptosis. Meayamycin B exhibits anticancer activity against non-small cell lung cancer[1].

IC50 & Target[1]

Mcl-1

 

Molecular Weight

576.72

Formula

C31H48N2O8
CAS No.
SMILES

O[C@H]1[C@@]2(CC(C)(O[C@@H]1/C=C/C(C)=C/C[C@H]3[C@H](C[C@H]([C@H](O3)C)NC(/C=C\[C@H](C)OC(N4CCOCC4)=O)=O)C)C)CO2
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Purity & Documentation
References
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Meayamycin B Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meayamycin B1020210-12-1(+)-Meayamycin BSF3B1Bcl-2 FamilyApoptosisSplicing Factor 3b Subunit 1non-small cell lung cancerA549H1299Inhibitorinhibitorinhibit

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