PDGFB - platelet derived growth factor subunit B Gene

Also Known as SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5155

About PDGFB

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,223,359-39,244,982 (from NCBI)

This gene has 4 transcripts (splice variants), 263 orthologues, 1 paralogue and is associated with 66 phenotypes. Broad expression in placenta (RPKM 18.6), fat (RPKM 12.7) and 23 other tissues.

Summary

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF Receptor Tyrosine Kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for Collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

PDGFB Products (2)

mRNA	Protein	Name
NM_002608.4	NP_002599.1	platelet-derived growth factor subunit B isoform 1 preproprotein
NM_033016.3	NP_148937.1	platelet-derived growth factor subunit B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chemoattractant activity	IDA IDA: Inferred from direct assay	21245381	GOA
enables collagen binding	IDA IDA: Inferred from direct assay	8900172	GOA
enables growth factor activity	IDA IDA: Inferred from direct assay	12070119	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	1396586	GOA
enables platelet-derived growth factor binding	IPI IPI: Inferred from physical interaction	7073684	GOA
enables platelet-derived growth factor receptor binding	EXP EXP: Inferred from Experiment	20534510	GOA
enables platelet-derived growth factor receptor binding	IDA IDA: Inferred from direct assay	2439522	GOA
enables platelet-derived growth factor receptor binding	IPI IPI: Inferred from physical interaction	2536956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	2536956	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	7073684	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	2836953	GOA
enables superoxide-generating NADPH oxidase activator activity	IDA IDA: Inferred from direct assay	17942966	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	16014047	GOA
involved in cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	21245381	GOA
involved in gene expression	IDA IDA: Inferred from direct assay	16530387	GOA
NOT involved in hemopoiesis	IMP IMP: Inferred from mutant phenotype	11264163	GOA
involved in interleukin-18-mediated signaling pathway	IDA IDA: Inferred from direct assay	21321938	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	24008408	GOA
involved in monocyte chemotaxis	IDA IDA: Inferred from direct assay	17991872	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	25089138	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	16530387	GOA
involved in negative regulation of miRNA transcription	IDA IDA: Inferred from direct assay	26493107	GOA
involved in negative regulation of phosphatidylinositol biosynthetic process	IDA IDA: Inferred from direct assay	2538439	GOA
involved in negative regulation of platelet activation	IDA IDA: Inferred from direct assay	2538439	GOA
involved in negative regulation of vascular associated smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	19088079	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	10734101	GOA
involved in platelet-derived growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	2439522	GOA
involved in positive regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	10644978	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17324121	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	11788434	GOA
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	9685360	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	11788434	GOA
involved in positive regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	9685360	GOA
involved in positive regulation of calcium ion import	IDA IDA: Inferred from direct assay	19019919	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	11788434	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	2439522	GOA
involved in positive regulation of cell-substrate adhesion	IDA IDA: Inferred from direct assay	19126672	GOA
involved in positive regulation of chemotaxis	IDA IDA: Inferred from direct assay	9409235	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	9685360	GOA
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	2439522	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	23554459	GOA
involved in positive regulation of glomerular mesangial cell proliferation	IDA IDA: Inferred from direct assay	11788434	GOA
involved in positive regulation of hyaluronan biosynthetic process	IDA IDA: Inferred from direct assay	17324121	GOA
involved in positive regulation of metanephric mesenchymal cell migration	IDA IDA: Inferred from direct assay	10734101	GOA
involved in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	IDA IDA: Inferred from direct assay	19019919	GOA
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	19088079	GOA
involved in positive regulation of mitotic nuclear division	IDA IDA: Inferred from direct assay	10644978	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	10734101	GOA
involved in positive regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	12070119	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	19019919	GOA
involved in positive regulation of smooth muscle cell migration	IDA IDA: Inferred from direct assay	9409235	GOA
involved in positive regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	21321938	GOA
involved in positive regulation of vascular associated smooth muscle cell dedifferentiation	IDA IDA: Inferred from direct assay	19088079	GOA
involved in positive regulation of vascular associated smooth muscle cell migration	IDA IDA: Inferred from direct assay	12070119	GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	12070119	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	17942966	GOA
involved in reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	17942966	GOA
involved in response to wounding	IDA IDA: Inferred from direct assay	2538439	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	291037	GOA
part of platelet-derived growth factor complex	IPI IPI: Inferred from physical interaction	7679113	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDGFB Protein Structure

PDGF_N

PDGF

0
100
200
241 a.a.

Protein Preferred Names	Protein Names
platelet-derived growth factor subunit B	PDGF subunit B

PDGFB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDGFB	P01127	PDGFB	Homo sapiens	P01127	X-Ray Diffraction	23139410
Intra	PDGFB	P01127	PDGFRA	Homo sapiens	P16234	Competition Binding	10806482
Intra	PDGFB	P01127	PDGFB	Homo sapiens	P01127	Electrophoresis	7679113
Intra	PDGFB	P01127	PDGFB	Homo sapiens	P01127	X-Ray Diffraction	1396586
Intra	PDGFB	P01127	PDGFRB	Homo sapiens	P09619	X-Ray Diffraction	20534510
Intra	PDGFB	P01127	PDGFRB	Homo sapiens	P09619	ELISA	17981115
Intra	PDGFB	P01127	PDGFRB	Homo sapiens	P09619	Competition Binding	10806482
Intra	PDGFB	P01127	PDGFRB	Homo sapiens	P09619	GMS	20534510
Intra	PDGFB	P01127	PDGFRB	Homo sapiens	P09619	Competition Binding	7679113
Intra	PDGFB	P01127	PDGFRB	Homo sapiens	P09619	ELISA	7679113
Intra	PDGFB	P01127	PDGFRA	Homo sapiens	P16234	Competition Binding	7679113
Intra	PDGFB	P01127	BCCIP	Homo sapiens	Q9P287	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDGFB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7055	PDGF-BB Protein, Human	P01127-1 (S82-T190)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7055A	PDGF-BB Protein, Human (P.pastoris)	P01127-1 (S82-T190)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7055G	GMP PDGF-BB Protein, Human	P01127-1 (S82-T190)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73351	PDGF-BB Protein, Human (P.pastoris, His)	P01127 (S82-T190)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7055B	PDGF-BB Protein, Human (His)	P01127-1 (S82-T190)	≥ 95%, as determined by reducing SDS-PAGE.

PDGFB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81811	PDGF B Antibody (YA1556)	WB, IHC-P	Human, Mouse, Rat
HY-P81811A	PDGF B Antibody (YA1556)(PBS only)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Dermatofibrosarcoma Protuberans	DFSP Dermatofibrosarcoma Giant Cell Fibroblastoma Metastatic Dermatofibrosarcoma Protuberans Familial Dermatofibrosarcoma Protuberans Darier-Ferrand Tumor Darier-Hoffmann Tumor
Basal Ganglia Calcification, Idiopathic, 5	IBGC5 Calcification, Basal Ganglia, Idiopathic, Type 5
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Basal Ganglia Calcification, Idiopathic, 1	Primary Familial Brain Calcification Pfbc Bspdc Bilateral Striopallidodentate Calcinosis Cerebrovascular Ferrocalcinosis IBGC1 Familial Idiopathic Basal Ganglia Calcification Idiopathic Basal Ganglia Calcification 1 Striopallidodentate Calcinosis, Bilateral Striopallidodentate Calcinosis, Autosomal Dominant, Adult-Onset Cerebral Calcification, Nonarteriosclerotic, Idiopathic, Adult-Onset Ferrocalcinosis, Cerebrovascular Fahr Disease, Familial, Formerly Basal Ganglia Calcification, Idiopathic, 3, Formerly Ibgc3, Formerly Basal Ganglia Calcification, Idiopathic, 2, Formerly Ibgc2, Formerly Fibgc Striopallidodentate Calcinosis Idiopathic Basal Ganglia Calcification Ferrocalcinosis Cerebro Vascular Autosomal Dominant Adult-Onset Striopallidodentate Calcinosis Familial Fahr Disease Ibgc2 Ibgc3 Idiopathic Basal Ganglia Calcification 2 Idiopathic Basal Ganglia Calcification 3 Non-Arteriosclerotic, Idiopathic, Adult-Onset Cerebral Calcification Basal Ganglia Calcification, Idiopathic Calcification, Basal Ganglia, Idiopathic Calcification, Basal Ganglia, Idiopathic, Type 1 Fahr'S Syndrome
Basal Ganglia Calcification	Fahr'S Syndrome Fahr'S Disease Fahr Disease
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Gingival Overgrowth	Gingival Enlargement Gingival Hyperplasia Gingival Bulge Gingival Enlargement Nos Gingival Hypertrophy Gum Hypertrophy Hyperplasia Gum Gingival Thickening Hyperplasia Of Gingiva Hypertrophy Of Gingiva Hypertrophy Of Mucous Membrane Of Gums
Cutaneous Fibrous Histiocytoma	Dermatofibroma Fibrohistiocytic Tumor Benign Cutaneous Fibrous Histiocytoma Fibrous Histiocytoma Of Skin Fibrous Xanthoma Of Skin Pleomorphic Fibroma Sclerosing Angioma Sclerosing Angioma Of Skin Fibrous Histiocytoma
Bronchiolitis Obliterans	Bronchiolitis Fibrosa Obliterans Obliterative Bronchiolitis Bronchiolitis Exudativa Bronchiolitis, Exudative
Chronic Ulcer Of Skin	Chronic Wounds Callous Ulcer Indolent Ulcer Chronic Ulcer
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Retinal Detachment	Retinal Detachments Rhegmatogenous Retinal Detachment Ruptured Retina With Detachment Retinal Hole With Detachment
Skin Sarcoma	Cutaneous Sarcoma
Arteriosclerosis	Arteriosclerotic Vascular Disease
Pulmonary Fibrosis	Fibrosis Of Lung
Glomerulonephritis	Bright'S Disease
Decubitus Ulcer	Pressure Ulcer Pressure Sores Pressure Ulcers Bedsore Decubitus Ulcer Decubitus Ulcer Any Site
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Costello Syndrome	Faciocutaneoskeletal Syndrome Fcs Syndrome Congenital Myopathy With Excess Of Muscle Spindles CSTLO CMEMS Fcss Myopathy, Congenital, With Excess Of Muscle Spindles
Glioma
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Desmoid Tumor	Aggressive Fibromatosis Desmoid Type Fibromatosis Familial Infiltrative Fibromatosis Desmoid Disorder, Hereditary Fif Fibromatosis, Familial Infiltrative Deep Fibromatosis Desmoid Fibromatosis Hereditary Desmoid Disease Musculoaponeurotic Fibromatosis Desmoid-Type Fibromatosis Fibromatosis, Aggressive Desmoid Disease, Hereditary Musculo-Aponeurotic Fibromatosis
Crouzon Syndrome With Acanthosis Nigricans	Crouzon Syndrome-Acanthosis Nigricans Syndrome CAN Crouzonodermoskeletal Syndrome Crouzon-Dermoskeletal Syndrome Crouzon, With Acanthosis Nigricans Syndrome
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Renal Fibrosis
Hemangioma	Hemangiomas
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Basal Ganglia Disease	Basal Ganglia Diseases Basal Ganglia Disorders Abnormality Of The Basal Ganglia
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Asbestos-Related Lung Carcinoma
Langerhans Cell Histiocytosis	Histiocytosis X Lch Langerhans Cell Granulomatosis Langerhans-Cell Histiocytosis Letterer-Siwe Disease Hashimoto-Pritzger Disease Histiocytosis, Langerhans-Cell Langerhan'S Cell Histiocytosis Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Involving Spleen Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Of Intrapelvic Lymph Nodes Letterer-Siwe Disease Of Intrathoracic Lymph Nodes Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Of Spleen Familial Letterer-Siwe Disease Langerhans-Cell Histiocytosis Nos
Infantile Myofibromatosis	Lipofibromatosis Myofibromatosis
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Pulmonary Plasma Cell Granuloma	Plasma Cell Granuloma, Pulmonary Granuloma, Plasma Cell, Pulmonary Lymphocytic Pseudotumor Of Lung Sclerosing Hemangiocytoma Of Lung
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Rhabdomyosarcoma
Iga Glomerulonephritis	Iga Nephropathy Glomerulonephritis, Iga Berger'S Iga Or Igg Nephropathy Focal Glomerulonephritis Primary Iga Nephropathy Segmental Glomerulonephritis Berger Disease Berger'S Disease Igan Nephritis, Iga Type Nephropathy Iga Glomerulonephritis Focal Iga Nephropathy, Susceptibility To Primary Immunoglobulin A Nephropathy
Microvascular Complications Of Diabetes 5	Diabetic Retinopathy Microvascular Complications Of Diabetes, Susceptibility To, 5 MVCD5 Retinopathy, Diabetic Diabetic Nephropathy Retinopathy, Diabetic, Susceptibility To Retinal Abnormality - Diabetes-Related
Familiar Ovarian Carcinoma
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Diffuse Midline Glioma, H3 K27m-Mutant	Diffuse Intrinsic Pontine Glioma Dipg Infiltrative Brainstem Glioma
Bronchiectasis 2
Sexual Sadism	Sadism
Exudative Vitreoretinopathy 1	Retinopathy Of Prematurity Retrolental Fibroplasia EVR1 Criswick-Schepens Syndrome Rop Exudative Vitreoretinopathy, Familial, Autosomal Dominant Fevr, Autosomal Dominant Premature Retinopathy Vitreoretinopathy, Exudative 1 Autosomal Dominant Familial Exudative Vitreoretinopathy Fevr Vitreoretinopathy, Exudative, Type 1 Retinopathy Of Prematurity Nos Rlf- [Retrolental Fibroplasia] Rop - [Retinopathy Of Prematurity] Terry Syndrome
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991724	Vasigrobart	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159059	Ganoderma lucidum polysaccharide		41.20%	Unkown
HY-160047	AX102 sodium		98.15%	Unkown
HY-RS17147	Pdgfb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-160048	PEG40K unconjugated/naked AX102 sodium		/	Unkown
HY-RS10251	PDGFB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174552	Human PDGFB mRNA		/	Unkown
HY-RS23596	Pdgfb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDGFB	MGD	MGI:97528
Rattus norvegicus	PDGFB	RGD	RGD:3283
Macaca mulatta	PDGFB	VGNC	VGNC:75927
Felis catus	PDGFB	VGNC	VGNC:68770
Canis familiaris	PDGFB	VGNC	VGNC:44369
Bos taurus	PDGFB	VGNC	VGNC:32690
Others	PDGFB	NCBI