(R)-MRT-6160
(R)-MRT-6160 is a molecular glue degrader targeting VAV1, with a DC50 of 40.93 nM. (R)-MRT-6160 induces VAV1 ubiquitination and proteasomal degradation by forming a CRBN-(R)-MRT-6160-VAV1 ternary complex, thereby inhibiting signaling downstream of the T/B cell receptor. (R)-MRT-6160 can be used in leukemia-related research.
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- CAS 番号: 3050683-63-8
- 分子式: C22H17ClN2O3
- 分子量:392.84
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3050683-63-8
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分子量 392.84
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分子式 C22H17ClN2O3
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SMILES
ClC1=C(C=CC=C1C2=CC=C(C=C2)N3C(=O)C=CC=C3)[C@@H]4C(=O)NC(=O)CC4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
(R)-MRT-6160 関連分類
HY-164773 関連分類
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Keywords
- (R)-MRT-6160
- 3050683-63-8
- Molecular Glues
- VAV1
- CRBN
- molecular glue degrader
- ternary complex
- ubiquitination
- proteasomal degradation
- targeted protein degradation (TPD)
- TCR signaling inhibition
- BCR signaling inhibition
- immunosuppression
- autoimmunity
- Jurkat cells
- primary human T cells
- primary human B cells
- Inhibitor
- inhibitor
- inhibit