3050683-63-8
3050683-63-8
Chemical Structure
(R)-MRT-6160
- CAS No.: 3050683-63-8
- Formula:C22H17ClN2O3
- Molecular Weight:392.84
IUPAC Name: (R)-3-(2-chloro-4'-(2-oxopyridin-1(2H)-yl)-[1,1'-biphenyl]-3-yl)piperidine-2,6-dione
InChIKey: RIFDPWJLHNZGEX-GOSISDBHSA-N
SMILES: ClC1=C(C=CC=C1C2=CC=C(C=C2)N3C(=O)C=CC=C3)[C@@H]4C(=O)NC(=O)CC4
Biological Activity: (R)-MRT-6160 is a molecular glue degrader targeting VAV1, with a DC50 of 40.93 nM. (R)-MRT-6160 induces VAV1 ubiquitination and proteasomal degradation by forming a CRBN-(R)-MRT-6160-VAV1 ternary complex, thereby inhibiting signaling downstream of the T/B cell receptor. (R)-MRT-6160 can be used in leukemia-related research[1].
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(R)-MRT-6160 | (R)-MRT-6160 is a molecular glue degrader targeting VAV1, with a DC50 of 40.93 nM. (R)-MRT-6160 induces VAV1 ubiquitination and proteasomal degradation by forming a CRBN-(R)-MRT-6160-VAV1 ternary complex, thereby inhibiting signaling downstream of the T/B cell receptor. (R)-MRT-6160 can be used in leukemia-related research. | |||||||||||||||||||||
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