3050683-03-6
Chemical Structure
MRT-23227
- CAS No.: 3050683-03-6
- Formula:C22H20ClN3O3
- Molecular Weight:409.87
IUPAC Name: 3-(2-chloro-4'-((1-methyl-1H-pyrazol-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)piperidine-2,6-dione
InChIKey: ATFVRCNMKWLFKW-UHFFFAOYSA-N
SMILES: O=C(C(C1=C(Cl)C(C2=CC=C(OCC3=NN(C)C=C3)C=C2)=CC=C1)CC4)NC4=O
Biological Activity: MRT-23227 is a CRBN-recruiting molecular glue degrader targeting VAV1. MRT-23227 binds to the tryptophan triad pocket of CRBN, forms a ternary complex with the SH3c domain of VAV1, and induces proteasomal degradation of VAV1 through hydrogen-bond interactions between CRBN residues and the RT loop and side chains of VAV1. MRT-23227 can be used in the research of T-cell leukemia and lymphoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MRT-23227 | 99.45% | MRT-23227 is a CRBN-recruiting molecular glue degrader targeting VAV1. MRT-23227 binds to the tryptophan triad pocket of CRBN, forms a ternary complex with the SH3c domain of VAV1, and induces proteasomal degradation of VAV1 through hydrogen-bond interactions between CRBN residues and the RT loop and side chains of VAV1. MRT-23227 can be used in the research of T-cell leukemia and lymphoma. | ||||||||||||||||||||
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