3050683-38-7
Chemical Structure
MRT-6160
Synonym(s): VAV1 degrader-3
- CAS No.: 3050683-38-7
- Formula:C22H17ClN2O3
- Molecular Weight:392.83
InChIKey: RIFDPWJLHNZGEX-UHFFFAOYSA-N
SMILES: ClC1=C(C2CCC(NC2=O)=O)C=CC=C1C3=CC=C(N4C(C=CC=C4)=O)C=C3
Biological Activity: MRT-6160 (Example 185) is an orally active VAV1 molecular glue degrader (DC50: 7 nM). MRT-6160 reduces immune cell activation, immune cell proliferation and the production of various cytokines. MRT-6160 can be used for research of inflammatory or autoimmune disorder. MRT-6160 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc.[1].
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MRT-6160 | 99.51% | MRT-6160 (Example 185) is an orally active VAV1 molecular glue degrader (DC50: 7 nM). MRT-6160 reduces immune cell activation, immune cell proliferation and the production of various cytokines. MRT-6160 can be used for research of inflammatory or autoimmune disorder. MRT-6160 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc.. | ||||||||||||||||||||
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Keywords
