CRBN ligand-13
Based on 1 Customer Validation
CRBN ligand-13 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.
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- Reinheit : 97.94%
- CAS. Nr.: 3050687-70-9
- Formel: C11H9BrClNO2
- Molecular Weight:302.55
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Speicherung:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
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Cereblon |
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3050687-70-9
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Appearance Solid
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Molecular Weight 302.55
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Formel C11H9BrClNO2
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Color White to off-white
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SMILES
O=C(C(C1=CC=CC(Br)=C1Cl)CC2)NC2=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : ≥ 50 mg/mL (165.26 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.3052 mL | 16.5262 mL | 33.0524 mL | 82.6310 mL |
| 5 mM | 0.6610 mL | 3.3052 mL | 6.6105 mL | 16.5262 mL | |
| 10 mM | 0.3305 mL | 1.6526 mL | 3.3052 mL | 8.2631 mL | |
| 15 mM | 0.2203 mL | 1.1017 mL | 2.2035 mL | 5.5087 mL | |
| 20 mM | 0.1653 mL | 0.8263 mL | 1.6526 mL | 4.1315 mL | |
| 25 mM | 0.1322 mL | 0.6610 mL | 1.3221 mL | 3.3052 mL | |
| 30 mM | 0.1102 mL | 0.5509 mL | 1.1017 mL | 2.7544 mL | |
| 40 mM | 0.0826 mL | 0.4132 mL | 0.8263 mL | 2.0658 mL | |
| 50 mM | 0.0661 mL | 0.3305 mL | 0.6610 mL | 1.6526 mL | |
| 60 mM | 0.0551 mL | 0.2754 mL | 0.5509 mL | 1.3772 mL | |
| 80 mM | 0.0413 mL | 0.2066 mL | 0.4132 mL | 1.0329 mL | |
| 100 mM | 0.0331 mL | 0.1653 mL | 0.3305 mL | 0.8263 mL |
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