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Cat. No.: HY-N17413

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(-)-γ-Cuparenol

(-)-γ-Cuparenol is a sesquiterpene compound with an IC₅₀ of 23.6 μg/mL against porcine Na⁺/K⁺-ATPase. (-)-γ-Cuparenol reduces phytohemagglutinin (PHA)-induced activation of NF-AT and NF-κB in Jurkat cells. (-)-γ-Cuparenol inhibits the growth of Gram-positive bacteria and some Gram-negative bacteria. (-)-γ-Cuparenol exhibits weak inhibitory activity against Candida albicans. (-)-γ-Cuparenol is applicable for research related to immunoregulation, cardiovascular diseases and bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 1357469-94-3
Formula: C₁₅H₂₂O
Molecular Weight:218.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(-)-γ-Cuparenol Chemical Structure

CAS No.: 1357469-94-3

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Biological Activity
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Chemical Information
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Biological Activity

Description

All NF-κB Isoforms :

In Vitro

(-)-γ-Cuparenol (10 μg/mL; 4 h) significantly reduces PHA-induced NF-AT and NF-κB activation in Jurkat T lymphocytes^[1].
(-)-γ-Cuparenol (0.05-100 μg/mL; 24 h ) inhibits the growth of Staphylococcus aureus, Bacillus subtilis, Micrococcus luteus, Proteus vulgaris, and Salmonella typhimurium with an MIC of 50 μg/mL, but does not inhibit Escherichia coli growth at concentrations up to 100 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1357469-94-3
Molecular Weight 218.33
Formula C₁₅H₂₂O
SMILES

C[C@@]1(C2=CC=C(C=C2)CO)C(C)(CCC1)C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Khongorzul Mendbayar, et al. New and Bioactive Sesquiterpenes from Schisandra sphenanthera. Wiley, 08 December 2011.

[2]. Oh I, et al. In vitro Na+/K+-ATPase inhibitory activity and antimicrobial activity of sesquiterpenes isolated from Thujopsis dolabrata. Arch Pharm Res. 2011;34(12):2141-2147. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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(-)-γ-Cuparenol

All NF-κB Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(-)-γ-Cuparenol Related Classifications

HY-N17413 Related Classifications