Licoisoflavanone
Based on 1 Customer Validation
Licoisoflavanone is an orally active isoflavane-based immunomodulator with multiple activities including antiviral, anti-inflammatory, cytoprotective and cancer cell apoptosis-inducing effects. Licoisoflavanone can be isolated from the roots and rhizomes of Glycyrrhiza uralensis Fisch. Licoisoflavanone not only enhances the body's immunity, but also effectively prevents acute respiratory distress syndrome and multiple organ damage by alleviating cytokine storm, thereby reducing the degree of inflammation. In rats, Licoisoflavanone undergoes multiple metabolic transformation processes such as glucuronidation, hydroxylation, sulfation, methylation and dehydrogenation. Licoisoflavanone has become an important candidate molecule for research on COVID-19 and related inflammatory diseases.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 96.74%
- CAS 番号: 66067-26-3
- 分子式: C20H18O6
- 分子量:354.35
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Licoisoflavanone (40 mg/kg; p.o.; single dose) shows no plasma detection but is present in high abundance in urine and feces, with glucuronidation and hydroxylation as its major in vivo metabolic reactions in male Sprague-Dawley rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats (male, 180-220 g)[2]
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Dosage:40 mg/kg
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Administration:p.o.; single dose
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Result:Was not detected in plasma, but was detected in high abundance in urine and feces.
Identified ten metabolites, including dihydroxylated, hydroxylated glucuronide, monohydroxylated, glucuronide, sulfate, methylated, and dehydrogenated glucuronide conjugates.
Confirmed glucuronidation and hydroxylation as the major metabolic reactions via β-glucuronidase treatment, which eliminated glucuronide peaks.
化学情報
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CAS 番号 66067-26-3
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性状 Solid
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分子量 354.35
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分子式 C20H18O6
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Color Light yellow to yellow
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SMILES
O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2O)COC4=CC(O)=CC(O)=C14
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Li yanhua, et al. CN113262246A. 2021-04-19.
[2]. Wang Q, et al. Metabolites identification of bioactive licorice compounds in rats. J Pharm Biomed Anal. 2015;115:515-522. [Content Brief]
[3]. Li xin, et al. CN103989736A. 2014-06-16.
[4]. Fu Y, et al. Deep learning-based network pharmacology for exploring the mechanism of licorice for the treatment of COVID-19. Sci Rep. 2023;13(1):5844. Published 2023 Apr 10. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Licoisoflavanone 関連分類
HY-N7372 関連分類
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