2. Apoptosis
  3. Apoptosis
  4. Licoisoflavanone

Licoisoflavanone is an orally active isoflavane-based immunomodulator with multiple activities including antiviral, anti-inflammatory, cytoprotective and cancer cell apoptosis-inducing effects. Licoisoflavanone can be isolated from the roots and rhizomes of Glycyrrhiza uralensis Fisch. Licoisoflavanone not only enhances the body's immunity, but also effectively prevents acute respiratory distress syndrome and multiple organ damage by alleviating cytokine storm, thereby reducing the degree of inflammation. In rats, Licoisoflavanone undergoes multiple metabolic transformation processes such as glucuronidation, hydroxylation, sulfation, methylation and dehydrogenation. Licoisoflavanone has become an important candidate molecule for research on COVID-19 and related inflammatory diseases.

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Licoisoflavanone

Licoisoflavanone Chemical Structure

CAS No. : 66067-26-3

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Licoisoflavanone Related Antibodies

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Description

Licoisoflavanone is an orally active isoflavane-based immunomodulator with multiple activities including antiviral, anti-inflammatory, cytoprotective and cancer cell apoptosis-inducing effects. Licoisoflavanone can be isolated from the roots and rhizomes of Glycyrrhiza uralensis Fisch. Licoisoflavanone not only enhances the body's immunity, but also effectively prevents acute respiratory distress syndrome and multiple organ damage by alleviating cytokine storm, thereby reducing the degree of inflammation. In rats, Licoisoflavanone undergoes multiple metabolic transformation processes such as glucuronidation, hydroxylation, sulfation, methylation and dehydrogenation. Licoisoflavanone has become an important candidate molecule for research on COVID-19 and related inflammatory diseases[1][2][3][4].
In Vivo

Licoisoflavanone (dietary; from day 110 of gestation to piglet weaning) is identified as one of 11 components present in the milk of lactating Large White sows given a compound traditional Chinese medicine[1].
Licoisoflavanone (40 mg/kg; p.o.; single dose) shows no plasma detection but is present in high abundance in urine and feces, with glucuronidation and hydroxylation as its major in vivo metabolic reactions in male Sprague-Dawley rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (male, 180-220 g)[2]
Dosage: 40 mg/kg
Administration: p.o.; single dose
Result: Was not detected in plasma, but was detected in high abundance in urine and feces.
Identified ten metabolites, including dihydroxylated, hydroxylated glucuronide, monohydroxylated, glucuronide, sulfate, methylated, and dehydrogenated glucuronide conjugates.
Confirmed glucuronidation and hydroxylation as the major metabolic reactions via β-glucuronidase treatment, which eliminated glucuronide peaks.
Molecular Weight

354.35

Formula

C20H18O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C(C2=CC=C3C(C=CC(C)(C)O3)=C2O)COC4=CC(O)=CC(O)=C14
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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Licoisoflavanone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Licoisoflavanone66067-26-3Apoptosisanti-inflammatory activityGlycyrrhiza uralensis Fisch.sow immunitycytokine stormsacute respiratory distress syndromecancer cellsantiviral activitycytoprotective activitySprague-Dawley ratsCOVID-19Inhibitorinhibitorinhibit

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