1. Anti-infection
  2. HCV
    SARS-CoV
  3. Mizoribine

Mizoribine (Synonyms: NSC 289637; HE 69)

Cat. No.: HY-17470 Purity: 99.98%
Handling Instructions

Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC50 of approximately 100 μM for anti-HCV activity. Immunosuppressant. Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively.

For research use only. We do not sell to patients.

Mizoribine Chemical Structure

Mizoribine Chemical Structure

CAS No. : 50924-49-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 115 In-stock
Estimated Time of Arrival: December 31
100 mg USD 200 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Mizoribine

    Mizoribine purchased from MCE. Usage Cited in: Molecules. 2019 May 3;24(9). pii: E1723.

    Guanosine supplementation attenuated the anti-FMDV effect of mizoribine. Serial dilutions of guanosine (from 100 to 25 μM) are added to FMDV (100 TCID50 O/MY98/BY/2010)-infected IBRS-2 cells, when treated with 75 μM mizoribine for 48 h. (A) The cell viability of cells and (B) FMDV VP1 levels are analyzed.
    • Biological Activity

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    Description

    Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC50 of approximately 100 μM for anti-HCV activity. Immunosuppressant[1]. Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively[2].

    IC50 & Target

    HCV[1]; IMPDH; SARS-CoV[2]

    In Vitro

    Mizoribine, isolated from culture medium of the mold Eupenicillium brefeldianum M-2166, acts as an immunosuppressant which exerts its effects without severe side effects[1].
    Mizoribine is an inosine-5′-monophosphate dehydrogenase (IMPDH) inhibitorused for renal transplantation, autoimmune diseases and steroid-resistant nephrotic syndrome [2].

    In Vivo

    Mizoribine suppresses collagen-induced arthritis. Mizoribine (10, 20 and 50 mg/kg; Administered orally 5 days a week for 12 weeks) reduces the arthritis score in a dose-dependent fashion, showing significant suppression, even at a dose of 10 mg/kg[3].

    Animal Model: Male DBA/1 J mice with collagen-induced arthritis[3]
    Dosage: 10, 20 and 50 mg/kg
    Administration: Administered orally 5 days a week for 12 weeks
    Result: Showed dose-dependency of the suppressive effect.
    Clinical Trial
    Molecular Weight

    259.22

    Formula

    C₉H₁₃N₃O₆

    CAS No.

    50924-49-7

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 35 mg/mL (135.02 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.8577 mL 19.2886 mL 38.5773 mL
    5 mM 0.7715 mL 3.8577 mL 7.7155 mL
    10 mM 0.3858 mL 1.9289 mL 3.8577 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (9.64 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    MizoribineNSC 289637HE 69NSC289637NSC-289637HE69HE-69HCVSARS-CoVHepatitis C virusSARS coronavirusnucleosideImmunosuppressantIMPDHInhibitorinhibitorinhibit

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    Cat. No.:
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