90729-42-3
90729-42-3
Chemical Structure
Carebastine
- CAS No.: 90729-42-3
- Formula:C32H37NO4
- Molecular Weight:499.64
IUPAC Name: 2-(4-(4-(4-(benzhydryloxy)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanoic acid
InChIKey: XGHOVGYJHWQGCC-UHFFFAOYSA-N
SMILES: O=C(CCCN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C4=CC=C(C=C4)C(C)(C(O)=O)C
Biological Activity: Carebastine is an Ebastine (HY-B0674) metabolite and H1-receptor antagonist. Carebastine inhibits VEGFR-2 and Akt phosphorylation. Carebastine exerts an anti-inflammatory effect by inhibiting MIF as well as TNF-α and IL-6 production. Carebastine shows anti-angiogenic activity[1][2]
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Carebastine | 99.23% | Carebastine is an Ebastine (HY-B0674) metabolite and H1-receptor antagonist. Carebastine inhibits VEGFR-2 and Akt phosphorylation. Carebastine exerts an anti-inflammatory effect by inhibiting MIF as well as TNF-α and IL-6 production. Carebastine shows anti-angiogenic activity | ||||||||||||||||||||
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Carebastine-d5 | Carebastine-d5 is the deuterium labeled Carebastine. Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner. Carebastine suppresses the expression of macrophage migration inhibitory factor. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.90
HY-122508Hydroxyebastine -
Similarity Score 0.88
HY-B0674Ebastine -
Similarity Score 0.69
HY-121356S1Carebastine-d5 Methyl Ester -
Similarity Score 0.67
HY-122508SHydroxy Ebastine-d5 -
Similarity Score 0.67
HY-B0801Fexofenadine -
Similarity Score 0.66
HY-B0801ARFexofenadine hydrochloride (Standard) -
Similarity Score 0.66
HY-B0674SEbastine-d5 -
Similarity Score 0.65
HY-108259HQL-79 -
Similarity Score 0.65
HY-143955SEbastine-d5 fumarate -
Explore the MedChemAI to find more analogs
References
- [1]. De Luisi A, et al. Anti-angiogenic activity of carebastine: a plausible mechanism affecting airway remodelling. Eur Respir J. 2009;34(4):958-966. [Content Brief]
- [2]. Zhao Y, et al. Carebastine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor. Clin Exp Dermatol. 2008 Nov;33(6):785-7.
