1. Immunology/Inflammation
  2. PGE synthase
  3. HQL-79

HQL-79 

Cat. No.: HY-108259 Purity: >99.0%
Handling Instructions

HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS.

For research use only. We do not sell to patients.

HQL-79 Chemical Structure

HQL-79 Chemical Structure

CAS No. : 162641-16-9

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Description

HQL-79 is a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1].

IC50 & Target

IC50: 6 μM (H-PGDS)[1]
Kd: 0.8 μM (H-PGDS)[1]

In Vitro

HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH[1].

Molecular Weight

377.48

Formula

C₂₂H₂₇N₅O

CAS No.

162641-16-9

SMILES

N1(CCCC2=NN=NN2)CCC(OC(C3=CC=CC=C3)C4=CC=CC=C4)CC1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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HQL-79
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