162641-16-9
162641-16-9
Chemical Structure
HQL-79
- CAS No.: 162641-16-9
- Formula:C22H27N5O
- Molecular Weight:377.48
IUPAC Name: 1-(3-(1H-tetrazol-5-yl)propyl)-4-(benzhydryloxy)piperidine
InChIKey: TZQGXAHOROZEKN-UHFFFAOYSA-N
SMILES: N1(CCCC2=NN=NN2)CCC(OC(C3=CC=CC=C3)C4=CC=CC=C4)CC1
Biological Activity: HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1].
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HQL-79 | 99.89% | HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS. | ||||||||||||||||||||
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HQL-79 (Standard) | HQL-79 (Standard) is the analytical standard of HQL-79 (HY-108259). This product is intended for research and analytical applications. HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS. | |||||||||||||||||||||
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References
Keywords
