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Cat. No.: HY-113964

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UK-78282

UK-78282 is a selective Kv1.3 voltage-gated potassium channel inhibitor with an IC₅₀ of 200 nM. UK-78282 also inhibit Kv1.4 potassium channel. UK-78282 can inhibit human T cell activation.

For research use only. We do not sell to patients.

CAS No.: 191217-42-2
Formula: C₂₉H₃₅NO₂
Molecular Weight:429.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

UK-78282 Chemical Structure

CAS No.: 191217-42-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Kv1.3

200 nM (IC₅₀)

Kv1.4

Cellular Effect

Cell Line	Type	Value	Description	References
L929	IC₅₀	200 nM Compound: UK-78282	Inhibition of Kv1.3 expressed in mouse L929 cells exposed to depolarizing step pulses from -80 mV to +40 mV by whole cell patch clamp method Inhibition of Kv1.3 expressed in mouse L929 cells exposed to depolarizing step pulses from -80 mV to +40 mV by whole cell patch clamp method	[PMID: 23084278]
T-cell	IC₅₀	0.2 μM Compound: UK-78282	In vitro inhibition of human T-cells voltage-gated potassium channel subunit Kv1.3 In vitro inhibition of human T-cells voltage-gated potassium channel subunit Kv1.3	10.1016/S0960-894X(97)00163-7
T-cell line	IC₅₀	0.4 μM Compound: 14a	In vitro inhibitory potency against human T-cells Rb efflux In vitro inhibitory potency against human T-cells Rb efflux	10.1016/S0960-894X(97)00163-7

Chemical Information

CAS No. 191217-42-2
Molecular Weight 429.59
Formula C₂₉H₃₅NO₂
SMILES

COC1=CC=C(CCCN2CCC(COC(C3=CC=CC=C3)C4=CC=CC=C4)CC2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hanson DC, et al. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr;126(8):1707-16. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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