2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Diphenylpyraline hydrochloride

Diphenylpyraline hydrochloride  (Synonyms: 4-Diphenylmethoxy-1-methylpiperidine hydrochloride)

Cat. No.: HY-B0970 Purity: 99.25%
COA Handling Instructions

Diphenylpyraline hydrochloride is a potent histamine H1 receptor antagonist. Diphenylpyraline hydrochloride acts as an orally active antihistamine agent with antimuscarinic and antiallergic effects. Diphenylpyraline hydrochloride can be used for the relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders in vivo.

For research use only. We do not sell to patients.

Diphenylpyraline hydrochloride Chemical Structure

Diphenylpyraline hydrochloride Chemical Structure

CAS No. : 132-18-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
500 mg USD 50 In-stock
1 g USD 60 In-stock
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10 g   Get quote  

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Diphenylpyraline hydrochloride Related Antibodies

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Description

Diphenylpyraline hydrochloride is a potent histamine H1 receptor antagonist. Diphenylpyraline hydrochloride acts as an orally active antihistamine agent with antimuscarinic and antiallergic effects. Diphenylpyraline hydrochloride can be used for the relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders in vivo.[1]

In Vitro

Diphenylpyraline hydrochloride (10 μM) markedly inhibits dopamine uptakein mouse nucleus accumbens slices[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diphenylpyraline hydrochloride Related Antibodies
In Vivo

Diphenylpyraline hydrochloride (intraperitoneal injection; 5-10 mg/kg) elevates extracellular dopamine levels (~200%) in mouse nucleus accumbens and induces locomotor activation in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[2]
Dosage: 5-10 mg/kg
Administration: Intraperitoneal injection
Result: Had psychostimulant properties.
Molecular Weight

317.85

Appearance

Solid

Formula

C19H24ClNO
CAS No.
SMILES

CN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (314.61 mM; Need ultrasonic)

DMSO : ≥ 100 mg/mL (314.61 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1461 mL 15.7307 mL 31.4614 mL
5 mM 0.6292 mL 3.1461 mL 6.2923 mL
10 mM 0.3146 mL 1.5731 mL 3.1461 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (314.61 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.87 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.87 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.25%

COA (250 KB) LCMS (112 KB)

Handling Instructions (2659 KB)
References
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Diphenylpyraline hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Diphenylpyraline132-18-34-Diphenylmethoxy-1-methylpiperidineHistamine Receptorallergicrhinitishay feverpruritic skin disordersParkinson’s diseasepsychostimulantInhibitorinhibitorinhibit

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