1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Diphenylpyraline hydrochloride

Diphenylpyraline hydrochloride (Synonyms: 4-Diphenylmethoxy-1-methylpiperidine hydrochloride)

Cat. No.: HY-B0970 Purity: 99.25%
Handling Instructions

Diphenylpyraline hydrochloride is a potent histamine H1 receptor antagonist. Diphenylpyraline hydrochloride acts as an orally active antihistamine agent with antimuscarinic and antiallergic effects. Diphenylpyraline hydrochloride can be used for the relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders in vivo.

For research use only. We do not sell to patients.

Diphenylpyraline hydrochloride Chemical Structure

Diphenylpyraline hydrochloride Chemical Structure

CAS No. : 132-18-3

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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Description

Diphenylpyraline hydrochloride is a potent histamine H1 receptor antagonist. Diphenylpyraline hydrochloride acts as an orally active antihistamine agent with antimuscarinic and antiallergic effects. Diphenylpyraline hydrochloride can be used for the relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders in vivo.[1]

In Vitro

Diphenylpyraline hydrochloride (10 μM) markedly inhibits dopamine uptakein mouse nucleus accumbens slices[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Diphenylpyraline hydrochloride (intraperitoneal injection; 5-10 mg/kg) elevates extracellular dopamine levels (~200%) in mouse nucleus accumbens and induces locomotor activation in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[2]
Dosage: 5-10 mg/kg
Administration: Intraperitoneal injection
Result: Had psychostimulant properties.
Molecular Weight

317.85

Formula

C19H24ClNO

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (314.61 mM; Need ultrasonic)

DMSO : ≥ 100 mg/mL (314.61 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1461 mL 15.7307 mL 31.4614 mL
5 mM 0.6292 mL 3.1461 mL 6.2923 mL
10 mM 0.3146 mL 1.5731 mL 3.1461 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (314.61 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.87 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.87 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.87 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.25%

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Diphenylpyraline hydrochloride
Cat. No.:
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