1. Anti-infection
    Metabolic Enzyme/Protease
  2. Bacterial
    Aminoacyl-tRNA Synthetase
  3. Epetraborole hydrochloride

Epetraborole hydrochloride  (Synonyms: GSK2251052 hydrochloride)

Cat. No.: HY-12479A Purity: 99.63%
COA Handling Instructions

Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research.

For research use only. We do not sell to patients.

Epetraborole hydrochloride Chemical Structure

Epetraborole hydrochloride Chemical Structure

CAS No. : 1234563-16-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 211 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 211 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 230 In-stock
Estimated Time of Arrival: December 31
25 mg USD 510 In-stock
Estimated Time of Arrival: December 31
50 mg USD 820 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Epetraborole hydrochloride

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research[1][2][3].

IC50 & Target

IC50: 0.31 μM (LeuRS)[3]

In Vitro

Epetraborole (0-32 μg/mL) shows anti-bacterial activity against key gram-negative aerobic and anaerobic pathogens and gram-positive anaerobes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Anaerobes isolates
Concentration: 0-32 μg/mL
Incubation Time:
Result: Showed MIC50/MIC90 for all anaerobes isolates tested of 2 and 4 μg/mL, respectively.
Clinical Trial
Molecular Weight

273.52

Formula

C11H17BClNO4

CAS No.
SMILES

OCCCOC1=C(B(O)O[[email protected]@H]2CN)C2=CC=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (731.21 mM; Need ultrasonic)

H2O : ≥ 28 mg/mL (102.37 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6560 mL 18.2802 mL 36.5604 mL
5 mM 0.7312 mL 3.6560 mL 7.3121 mL
10 mM 0.3656 mL 1.8280 mL 3.6560 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (365.60 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: ≥ 2.5 mg/mL (9.14 mM); Clear solution

  • 3.

    Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.14 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.63%

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Epetraborole hydrochloride
Cat. No.:
HY-12479A
Quantity:
MCE Japan Authorized Agent: