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Epetraborole hydrochloride (Synonyms: GSK2251052 hydrochloride)

Cat. No.: HY-12479A Purity: 99.27%
Handling Instructions

Epetraborole hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor, which inhibits protein synthesis by binding "to the terminal adenosine ribose (A76) of leucyl-tRNA synthetase".

For research use only. We do not sell to patients.

Epetraborole hydrochloride Chemical Structure

Epetraborole hydrochloride Chemical Structure

CAS No. : 1234563-16-6

Size Price Stock Quantity
10 mM * 1 mL in Water USD 181 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
50 mg USD 450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Epetraborole hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor, which inhibits protein synthesis by binding "to the terminal adenosine ribose (A76) of leucyl-tRNA synthetase". It is intended for the treatment of infections caused by Gram-negative bacteria. Epetraborole hydrochloride is a bacteriostatic compound that can against a wide range of anaerobic and Gram-negative bacteria, including multidrug-resistant pathogens, such as extended-spectrum-β-lactamase-, metallo-β-lactamase-, and carbapenemase-producing organism.

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O : ≥ 28 mg/mL (102.37 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6560 mL 18.2802 mL 36.5604 mL
5 mM 0.7312 mL 3.6560 mL 7.3121 mL
10 mM 0.3656 mL 1.8280 mL 3.6560 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

273.52

Formula

C₁₁H₁₇BClNO₄

CAS No.

1234563-16-6

SMILES

OCCCOC1=C(B(O)O[[email protected]@H]2CN)C2=CC=C1.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.27%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Epetraborole hydrochloride
Cat. No.:
HY-12479A
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Epetraborole hydrochloride

Cat. No.: HY-12479A