1. Anti-infection
  2. Bacterial
  3. Epetraborole hydrochloride

Epetraborole hydrochloride (Synonyms: GSK2251052 hydrochloride)

Cat. No.: HY-12479A Purity: 99.65%
Handling Instructions

Epetraborole hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor, which inhibits protein synthesis by binding "to the terminal adenosine ribose (A76) of leucyl-tRNA synthetase".

For research use only. We do not sell to patients.

Epetraborole hydrochloride Chemical Structure

Epetraborole hydrochloride Chemical Structure

CAS No. : 1234563-16-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 256 In-stock
Estimated Time of Arrival: December 31
1 mg USD 85 In-stock
Estimated Time of Arrival: December 31
5 mg USD 165 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
25 mg USD 570 In-stock
Estimated Time of Arrival: December 31
50 mg USD 980 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

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Description

Epetraborole hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor, which inhibits protein synthesis by binding "to the terminal adenosine ribose (A76) of leucyl-tRNA synthetase". It is intended for the treatment of infections caused by Gram-negative bacteria. Epetraborole hydrochloride is a bacteriostatic compound that can against a wide range of anaerobic and Gram-negative bacteria, including multidrug-resistant pathogens, such as extended-spectrum-β-lactamase-, metallo-β-lactamase-, and carbapenemase-producing organism.

Clinical Trial
Molecular Weight

273.52

Formula

C₁₁H₁₇BClNO₄

CAS No.

1234563-16-6

SMILES

OCCCOC1=C(B(O)O[[email protected]@H]2CN)C2=CC=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (731.21 mM; Need ultrasonic)

H2O : ≥ 28 mg/mL (102.37 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6560 mL 18.2802 mL 36.5604 mL
5 mM 0.7312 mL 3.6560 mL 7.3121 mL
10 mM 0.3656 mL 1.8280 mL 3.6560 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  1% DMSO    99% saline

    Solubility: ≥ 0.5 mg/mL (1.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: ≥ 2.5 mg/mL (9.14 mM); Clear solution

  • 3.

    Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.14 mM); Clear solution

  • 4.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (365.60 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 99.65%

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Keywords:

EpetraboroleGSK2251052GSK 2251052GSK-2251052BacterialInhibitorinhibitorinhibit

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Product Name:
Epetraborole hydrochloride
Cat. No.:
HY-12479A
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