1. Immunology/Inflammation
  2. PGE synthase

Limaprost (Synonyms: 17α,20-dimethyl-δ2-PGE1; ONO1206; OP1206)

Cat. No.: HY-B0683 Purity: 99.76%
Handling Instructions

Limaprost(OP1206) is a PGE1 analog and potent platelet adhesion inhibitor.

For research use only. We do not sell to patients.

Limaprost Chemical Structure

Limaprost Chemical Structure

CAS No. : 74397-12-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 221 In-stock
Estimated Time of Arrival: December 31
2 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 264 In-stock
Estimated Time of Arrival: December 31
10 mg USD 492 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1980 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Limaprost(OP1206) is a PGE1 analog and potent platelet adhesion inhibitor. Target: Others Limaprost, an alprostadil (prostaglandin E1) analogue, is a vasodilator that increases blood flow and inhibits platelet aggregation. Limaprost is a n analog of PGE1 with structural modifications intended to give a prolonged half-life and greater potency. It is orally active in both guinea pigs and rats at doses of 100 mg/kg as an inhibitor of ADP and collagen induced platelet aggregation. It is 10-1,000 times more potent than PGE1 as a platelet adhesive inhibitor, measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 mg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 mg/kg orally in rats [1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 40 mg/mL (105.12 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6280 mL 13.1399 mL 26.2798 mL
5 mM 0.5256 mL 2.6280 mL 5.2560 mL
10 mM 0.2628 mL 1.3140 mL 2.6280 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

380.52

Formula

C₂₂H₃₆O₅

CAS No.

74397-12-9

SMILES

O=C(O)/C=C/CCCC[[email protected]@H]1[[email protected]@H](/C=C/[[email protected]@H](O)C[[email protected]@H](C)CCCC)[[email protected]](O)CC1=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Limaprost
Cat. No.:
HY-B0683
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Limaprost

Cat. No.: HY-B0683