116680-01-4
Chemical Structure
Mycophenolate mofetil hydrochloride
Synonym(s): RS 61443 hydrochloride; TM-MMF hydrochloride
- CAS No.: 116680-01-4
- Formula:C23H32ClNO7
- Molecular Weight:469.96
IUPAC Name: 2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoate hydrochloride
InChIKey: OWLCGJBUTJXNOF-HDNKIUSMSA-N
SMILES: O=C(OCCN1CCOCC1)CC/C(C)=C/CC2=C(O)C3=C(COC3=O)C(C)=C2OC.Cl
Biological Activity: Mycophenolate mofetil (RS 61443; TM-MMF) hydrochloride is an orally active antimetabolic immunosuppressant with antiproliferative and anti-inflammatory properties. Mycophenolate mofetil hydrochloride significantly inhibits the production of B, T lymphocytes and the proliferation of smooth muscle cells by selectively blocking the de novo purine synthesis pathway. Mycophenolate mofetil hydrochloride effectively reduces adventitial inflammation, medial necrosis and intimal thickening in rat aortic allografts, and decreases the number of lymphocytes expressing the IL-2 receptor, thereby delaying xenograft rejection. Mycophenolate mofetil hydrochloride shows certain toxicity in a hamster-to-rat limb xenotransplantation model when used in combination with FK506 (HY-13756). Mycophenolate mofetil hydrochloride is widely used in studies related to allograft arteriosclerosis (chronic rejection)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mycophenolate mofetil hydrochloride | 99.82% | Mycophenolate mofetil (RS 61443; TM-MMF) hydrochloride is an orally active antimetabolic immunosuppressant with antiproliferative and anti-inflammatory properties. Mycophenolate mofetil hydrochloride significantly inhibits the production of B, T lymphocytes and the proliferation of smooth muscle cells by selectively blocking the de novo purine synthesis pathway. Mycophenolate mofetil hydrochloride effectively reduces adventitial inflammation, medial necrosis and intimal thickening in rat aortic allografts, and decreases the number of lymphocytes expressing the IL-2 receptor, thereby delaying xenograft rejection. Mycophenolate mofetil hydrochloride shows certain toxicity in a hamster-to-rat limb xenotransplantation model when used in combination with FK506 (HY-13756). Mycophenolate mofetil hydrochloride is widely used in studies related to allograft arteriosclerosis (chronic rejection). | ||||||||||||||||||||
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Mycophenolate Mofetil-d4 (hydrochloride) | Mycophenolate Mofetil-d4 hydrochloride is deuterated labeled Mycophenolate mofetil hydrochloride (HY-B0199A). Mycophenolate mofetil (RS 61443; TM-MMF) hydrochloride is an orally active antimetabolic immunosuppressant with antiproliferative and anti-inflammatory properties. Mycophenolate mofetil hydrochloride significantly inhibits the production of B, T lymphocytes and the proliferation of smooth muscle cells by selectively blocking the de novo purine synthesis pathway. Mycophenolate mofetil hydrochloride effectively reduces adventitial inflammation, medial necrosis and intimal thickening in rat aortic allografts, and decreases the number of lymphocytes expressing the IL-2 receptor, thereby delaying xenograft rejection. Mycophenolate mofetil hydrochloride shows certain toxicity in a hamster-to-rat limb xenotransplantation model when used in combination with FK506 (HY-13756). Mycophenolate mofetil hydrochloride is widely used in studies related to allograft arteriosclerosis (chronic rejection). | |||||||||||||||||||||
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Similarity Score 0.99
HY-B0199Mycophenolate Mofetil -
Similarity Score 0.89
HY-Z19687Mycophenolate impurity 3 -
Similarity Score 0.87
HY-Z8510Mycophenolate impurity 1 -
Similarity Score 0.84
HY-Z8512Mycophenolate impurity 4 -
Similarity Score 0.77
HY-137238Ethyl mycophenolate -
Similarity Score 0.76
HY-B0199SMycophenolate Mofetil-d4 -
Similarity Score 0.75
HY-113972A(E/Z)-Methyl mycophenolate -
Similarity Score 0.75
HY-113972RMethyl mycophenolate (Standard) -
Similarity Score 0.74
HY-B0421ARMycophenolic acid sodium (Standard) -
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References
- [1]. Räisänen-Sokolowski A, et al. Mycophenolate mofetil (MMF, RS-61443) inhibits inflammation and smooth muscle cell proliferation in rat aortic allografts. Transpl Immunol. 1995;3(4):342-351. [Content Brief]
- [2]. Hebebrand D, et al. Limb xenotransplantation using FK506 and RS61443 immunosuppression. J Reconstr Microsurg. 1998;14(3):191-194. [Content Brief]
