nAChR antagonist 2
nAChR antagonist 2 is a selective nAChR antagonist. nAChR antagonist 2 inhibits nAChR subtype including hα9α10, hα9, and hα7 with IC50 values of 16.0 nM, 26.2 nM, and 336.3 nM, respectively, in Xenopus oocytes. nAChR antagonist 2 suppresses ATP-induced IL-1β release at nanomolar concentrations. nAChR antagonist 2 can be used for nonopioid analgesics and immunomodulators research.
For research use only. We do not sell to patients.
- Formula: C23H32INO2
- Molecular Weight:481.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-1β |
nAChR antagonist 2 (compound 22) (300 pM-30 μM, 3 min) selectively inhibits ACh-evoked currents mediated by α9-containing nAChRs expressed in Xenopus oocytes, with IC50 values of 16.0 nM, 26.2 nM, and 336.3 nM for hα9α10, hα9, and hα7, respectively[1].
nAChR antagonist 2 (100 pM or 100 nM, 40 min) exerts both antagonistic and agonistic functions at the NCNRs of monocytic THP-1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1 cells were primed with Lipopolysaccharide (HY-D1056) (1 μg/mL, 5 h), followed by 40 min of BzATP triethylammonium salt (HY-136254) (40 min)[1]
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Concentration:100 pM or 100 nM
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Incubation Time:40 min
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Result:Efficiently antagonized the inhibitory effect of Ach at 100 pM.
Exhibted mild antagonistic effects at higher 100nM.
Effectively and significantly inhibited the BzATP (HY-136254)-induced release of IL-1β in the absence of ACh.
Chemical Information
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Molecular Weight 481.41
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Formula C23H32INO2
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SMILES
C[N+](CCOC1=CC=C(COC2=CC=CC=C2)C=C1)(C)C3CCCCC3.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
nAChR antagonist 2 Related Classifications
HY-180559 Related Classifications
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