2. Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation
  3. nAChR Interleukin Related
  4. nAChR antagonist 2

nAChR antagonist 2 is a selective nAChR antagonist. nAChR antagonist 2 inhibits nAChR subtype including hα9α10, hα9, and hα7 with IC50 values of 16.0 nM, 26.2 nM, and 336.3 nM, respectively, in Xenopus oocytes. nAChR antagonist 2 suppresses ATP-induced IL-1β release at nanomolar concentrations. nAChR antagonist 2 can be used for nonopioid analgesics and immunomodulators research.

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nAChR antagonist 2

nAChR antagonist 2 Chemical Structure

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nAChR antagonist 2 Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

nAChR antagonist 2 is a selective nAChR antagonist. nAChR antagonist 2 inhibits nAChR subtype including hα9α10, hα9, and hα7 with IC50 values of 16.0 nM, 26.2 nM, and 336.3 nM, respectively, in Xenopus oocytes. nAChR antagonist 2 suppresses ATP-induced IL-1β release at nanomolar concentrations. nAChR antagonist 2 can be used for nonopioid analgesics and immunomodulators research[1].

IC50 & Target[1]

IL-1β

 

In Vitro

nAChR antagonist 2 (compound 22) (300 pM-30 μM, 3 min) selectively inhibits ACh-evoked currents mediated by α9-containing nAChRs expressed in Xenopus oocytes, with IC50 values of 16.0 nM, 26.2 nM, and 336.3 nM for hα9α10, hα9, and hα7, respectively[1].
nAChR antagonist 2 (100 pM or 100 nM, 40 min) exerts both antagonistic and agonistic functions at the NCNRs of monocytic THP-1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

nAChR antagonist 2 Related Antibodies

ELISA Assay[1]

Cell Line: THP-1 cells were primed with Lipopolysaccharide (HY-D1056) (1 μg/mL, 5 h), followed by 40 min of BzATP triethylammonium salt (HY-136254) (40 min)[1]
Concentration: 100 pM or 100 nM
Incubation Time: 40 min
Result: Efficiently antagonized the inhibitory effect of Ach at 100 pM.
Exhibted mild antagonistic effects at higher 100nM.
Effectively and significantly inhibited the BzATP (HY-136254)-induced release of IL-1β in the absence of ACh.
Molecular Weight

481.41

Formula

C23H32INO2
SMILES

C[N+](CCOC1=CC=C(COC2=CC=CC=C2)C=C1)(C)C3CCCCC3.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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nAChR antagonist 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

nAChR antagonist 2nAChR antagonist2nAChR antagonist-2nAChRInterleukin RelatedNicotinic acetylcholine receptorsILnAChR antagonistIL-1β releasenonopioid analgesicsimmunomodulatorsInhibitorinhibitorinhibit

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