62025-48-3
Chemical Structure
Mizoribine 5'-monophosphate
Synonym(s): MZR-P
- CAS No.: 62025-48-3
- Formula:C9H14N3O9P
- Molecular Weight:339.20
IUPAC Name: ((2R,3S,4R,5R)-5-(4-carbamoyl-5-hydroxy-1H-imidazol-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate
InChIKey: KTKAFSMJDTUUAN-UUOKFMHZSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](N2C(O)=C(C(N)=O)N=C2)O[C@@H]1COP(O)(O)=O
Biological Activity: Mizoribine 5'-monophosphate (MZR-P) is the active metabolite of Mizoribine (HY-17470). Mizoribine 5'-monophosphate is an inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), and its Ki values for IMPDH of Trypanosoma brucei, Bacillus subtilis and Oceanobacillus iheyensis are 3.3, 72 and 157 nM respectively. Mizoribine 5'-monophosphate can be used in anti-trypanosomiasis and immunosuppression research[1][2].
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Mizoribine 5'-monophosphate | Mizoribine 5'-monophosphate (MZR-P) is the active metabolite of Mizoribine (HY-17470). Mizoribine 5'-monophosphate is an inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), and its Ki values for IMPDH of Trypanosoma brucei, Bacillus subtilis and Oceanobacillus iheyensis are 3.3, 72 and 157 nM respectively. Mizoribine 5'-monophosphate can be used in anti-trypanosomiasis and immunosuppression research. | |||||||||||||||||||||
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- [1]. Ota H, et al. A novel enzymatic method for measuring mizoribine 5'-monophosphate levels in serum. J Biosci Bioeng. 2008 Nov;106(5):511-4. [Content Brief]
- [2]. Bessho T, et al. Characterization of the novel Trypanosoma brucei inosine 5'-monophosphate dehydrogenase. Parasitology. 2013 May;140(6):735-45. [Content Brief]
Keywords
