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Neutrophil elastase-IN-7

32 Cited Publications
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Based on 32 publication(s) in Google Scholar

Neutrophil elastase-IN-7 (Compound 12) is an effective inhibitor of neutrophil elastase (HNE), with an IC50 value of 0.54 μM. Neutrophil elastase-IN-7 also exhibits significant inhibitory activity against various coagulation proteins, with the IC50 values for thrombin, FXa, FXIa, and FXIIIa being 8.2, 12.7, 1.2, and 5.7 μM, respectively. Neutrophil elastase-IN-7 can be used for research on inflammation, innate immune responses, and tissue remodeling.

For research use only. We do not sell to patients.

  • CAS No.: 6968-33-8
  • Formula: C34H28N6O14S4
  • Molecular Weight:872.88
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Neutrophil elastase-IN-7 Chemical Structure
    Neutrophil elastase-IN-7 Chemical Structure
  • Experimental Validation Results for Neutrophil elastase-IN-7
  • Experimental Validation Results for Neutrophil elastase-IN-7
  • Experimental Validation Results for Neutrophil elastase-IN-7
  • Experimental Validation Results for Neutrophil elastase-IN-7
  • Experimental Validation Results for Neutrophil elastase-IN-7
CAS No.: 6968-33-8
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  • Neutrophil elastase-IN-7 Chemical Structure
    Neutrophil elastase-IN-7 Chemical Structure
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    Neutrophil elastase-IN-7 purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Oct 4;330(Pt 3):148106. [Abstract]

    Customer Validation
     Representative images of injured spinal cord in the control, ZFgf11a, and MFGF11b groups after Evans Blue (EB, 2 mL/kg, i.v.; single dose) dye injection at 4 dpi.

  • 1/16

    Neutrophil elastase-IN-7 purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Oct 4;330(Pt 3):148106. [Abstract]

    Customer Validation
     Representative immunofluorescence images of Evans Blue (EB, 2 mL/kg, i.v.; single dose) extravasation at the lesion epicenter in the transverse sections of the spinal cord in the control, ZFgf11a, and MFGF11b groups at 4 dpi.

  • 1/16

    Neutrophil elastase-IN-7 purchased from MedChemExpress. Usage Cited in: Cancer Immunol Immunother. 2025 Jul 12;74(8):268. [Abstract]

    Customer Validation
     Representative images of Evans blue (4 ml/kg; i.v.; single dose) leakage and the difference between TGF-β3 and PBS groups (n = 5).

  • 1/16

    Neutrophil elastase-IN-7 purchased from MedChemExpress. Usage Cited in: Adv Healthc Mater. 2024 Jan;13(3):e2302320. [Abstract]

    Customer Validation
     The effects of different groups (control, CLP, Ca-MOF, Zolif, CMZ, RCMZ, and γ3-RCMZ) on CLP-induced vascular permeability were examined by measuring Evans blue dye in peritoneal washings. Evans blue (10 mg/kg; i.v.; single dose) injection revealed that γ3-RCMZ effectively reduced endothelial leakage levels to one-sixth of those observed in the CLP group, indicating its predominant antiendothelial leakage effect in sepsis.

  • 1/16

    Neutrophil elastase-IN-7 purchased from MedChemExpress. Usage Cited in: Theranostics. 2023 Jun 26;13(11):3761-3780. [Abstract]

    Customer Validation
     Sufu-cKO and WT mice were intraperitoneally injected with PBS or LPS (5 mg/kg) for 23 h, then injected with Evans blue dye (30 mg/kg body weight; i.v.; single dose) for an additional 40 min before mice were killed and lung tissues harvested. Means ± SEM (n = 5).

  • Neutrophil elastase-IN-7