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Evans Blue

(Synonyms: Direct Blue 53; T-1824; C.I. 23860)
29 Cited Publications
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Based on 29 publication(s) in Google Scholar

Evans Blue (Direct Blue 53) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability.

For research use only. We do not sell to patients.

  • Purity: 99.86%
  • CAS No.: 314-13-6
  • Formula: C34H24N6Na4O14S4
  • Molecular Weight:960.81
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Evans Blue Chemical Structure
    Evans Blue Chemical Structure
  • Experimental Validation Results for Evans Blue
  • Experimental Validation Results for Evans Blue
  • Experimental Validation Results for Evans Blue
  • Experimental Validation Results for Evans Blue
  • Experimental Validation Results for Evans Blue
CAS No.: 314-13-6
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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In Vivo Efficacy StudyIF
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  • Evans Blue Chemical Structure
    Evans Blue Chemical Structure
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    Evans Blue purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Oct 4;330(Pt 3):148106. [Abstract]

    Customer Validation
     Representative images of injured spinal cord in the control, ZFgf11a, and MFGF11b groups after Evans Blue (EB, 2 mL/kg, i.v.; single dose) dye injection at 4 dpi.

  • 1/16

    Evans Blue purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Oct 4;330(Pt 3):148106. [Abstract]

    Customer Validation
     Representative immunofluorescence images of Evans Blue (EB, 2 mL/kg, i.v.; single dose) extravasation at the lesion epicenter in the transverse sections of the spinal cord in the control, ZFgf11a, and MFGF11b groups at 4 dpi.

  • 1/16

    Evans Blue purchased from MedChemExpress. Usage Cited in: Cancer Immunol Immunother. 2025 Jul 12;74(8):268. [Abstract]

    Customer Validation
     Representative images of Evans blue (4 ml/kg; i.v.; single dose) leakage and the difference between TGF-β3 and PBS groups (n = 5).

  • 1/16

    Evans Blue purchased from MedChemExpress. Usage Cited in: Adv Healthc Mater. 2024 Jan;13(3):e2302320. [Abstract]

    Customer Validation
     The effects of different groups (control, CLP, Ca-MOF, Zolif, CMZ, RCMZ, and γ3-RCMZ) on CLP-induced vascular permeability were examined by measuring Evans blue dye in peritoneal washings. Evans blue (10 mg/kg; i.v.; single dose) injection revealed that γ3-RCMZ effectively reduced endothelial leakage levels to one-sixth of those observed in the CLP group, indicating its predominant antiendothelial leakage effect in sepsis.

  • 1/16

    Evans Blue purchased from MedChemExpress. Usage Cited in: Theranostics. 2023 Jun 26;13(11):3761-3780. [Abstract]

    Customer Validation
     Sufu-cKO and WT mice were intraperitoneally injected with PBS or LPS (5 mg/kg) for 23 h, then injected with Evans blue dye (30 mg/kg body weight; i.v.; single dose) for an additional 40 min before mice were killed and lung tissues harvested. Means ± SEM (n = 5).

  • Evans Blue