314-13-6
Chemical Structure
Evans Blue
Synonym(s): Direct Blue 53; T-1824; C.I. 23860
- CAS No.: 314-13-6
- Formula:C34H24N6Na4O14S4
- Molecular Weight:960.81
IUPAC Name: sodium 6,6'-((1E,1'E)-(3,3'-dimethyl-[1,1'-biphenyl]-4,4'-diyl)bis(diazene-2,1-diyl))bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate)
InChIKey: ATNOAWAQFYGAOY-GPTZEZBUSA-J
SMILES: CC1=CC(C2=CC=C(/N=N/C3=C(O)C4=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C4C=C3)C(C)=C2)=CC=C1/N=N/C5=C(O)C6=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C6C=C5
Biological Activity: Evans Blue (Direct Blue 53; T-1824; C.I. 23860) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Evans Blue | 99.86% | Evans Blue (Direct Blue 53; T-1824; C.I. 23860) is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Evans Blue is a L-glutamate and kainate receptor-mediated currents inhibitor. Evans Blue has a strong affinity towards serum albumin, making it a high molecular weight protein tracer. Evans Blue is also used to study BBB (blood-brain barrier) permeability. | ||||||||||||||||||||
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References
- [1]. Yao L, et al. Evans Blue Dye: A Revisit of Its Applications in Biomedicine. Contrast media & molecular imaging. 2018;2018:7628037. [Content Brief]
- [2]. Manaenko A, et al. Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model. J Neurosci Methods. 2011 Feb 15;195(2):206-10. [Content Brief]
- [3]. Ahishali B, et al. Evaluation of Blood-Brain Barrier Integrity Using Vascular Permeability Markers: Evans Blue, Sodium Fluorescein, Albumin-Alexa Fluor Conjugates, and Horseradish Peroxidase. Methods in molecular biology (Clifton, N.J.). 2021;2367:87-103.
- [4]. Smith P, et al. Measurement of Lung Vessel and Epithelial Permeability In Vivo with Evans Blue. Methods Mol Biol. 2021;2367:137-148.
- [5]. Linpeng Yao, et al. Evans Blue Dye: A Revisit of Its Applications in Biomedicine. Contrast Media Mol Imaging. 2018 Apr 22:2018:7628037.
