6968-33-8
Chemical Structure
Neutrophil elastase-IN-7
- CAS No.: 6968-33-8
- Formula:C34H28N6O14S4
- Molecular Weight:872.88
IUPAC Name: 6,6'-((1E,1'E)-(3,3'-dimethyl-[1,1'-biphenyl]-4,4'-diyl)bis(diazene-2,1-diyl))bis(4-amino-5-hydroxynaphthalene-1,3-disulfonic acid)
InChIKey: COXVTLYNGOIATD-HVMBLDELSA-N
SMILES: O=S(O)(C1=CC(S(=O)(O)=O)=C2C=CC(/N=N/C3=CC=C(C4=CC=C(C(C)=C4)/N=N/C(C=CC5=C(S(=O)(O)=O)C=C6S(=O)(O)=O)=C(O)C5=C6N)C=C3C)=C(C2=C1N)O)=O
Biological Activity: Neutrophil elastase-IN-7 (Compound 12) is an effective inhibitor of neutrophil elastase (HNE), with an IC50 value of 0.54 μM. Neutrophil elastase-IN-7 also exhibits significant inhibitory activity against various coagulation proteins, with the IC50 values for thrombin, FXa, FXIa, and FXIIIa being 8.2, 12.7, 1.2, and 5.7 μM, respectively. Neutrophil elastase-IN-7 can be used for research on inflammation, innate immune responses, and tissue remodeling[1].
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Neutrophil elastase-IN-7 | Neutrophil elastase-IN-7 (Compound 12) is an effective inhibitor of neutrophil elastase (HNE), with an IC50 value of 0.54 μM. Neutrophil elastase-IN-7 also exhibits significant inhibitory activity against various coagulation proteins, with the IC50 values for thrombin, FXa, FXIa, and FXIIIa being 8.2, 12.7, 1.2, and 5.7 μM, respectively. Neutrophil elastase-IN-7 can be used for research on inflammation, innate immune responses, and tissue remodeling. | |||||||||||||||||||||
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Keywords
