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Cat. No.: HY-184899

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Sirt1/CXCR3-IN-1

Sirt1/CXCR3-IN-1 is a dual Sirt1/CXCR3 inhibitor with an IC₅₀ of 0.77 μM against Sirt1. Sirt1/CXCR3-IN-1 inhibits dengue virus replication, upregulates the expression of interferon-stimulated genes, and enhances the antiviral defense capacity of the host. Sirt1/CXCR3-IN-1 suppresses CXCR3-mediated T cell chemotaxis and cytokine release, thereby reducing immune activation and inflammatory responses. Sirt1/CXCR3-IN-1 is applicable to research related to dengue virus infection.

For research use only. We do not sell to patients.

Formula: C₃₂H₃₂N₄O₄
Molecular Weight:536.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sirt1/CXCR3-IN-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

SIRT1

0.77 μM (IC₅₀)

CXCR3

All Sirtuin Isoforms :

All CXCR Isoforms :

In Vitro

Sirt1/CXCR3-IN-1 (Compound 7D) inhibits CXCR3-mediated immune cell chemotaxis and cytokine release by disrupting the CXCR3-CXCL4 interaction and stabilizing CXCR3 in an inactive state^[1].
Sirt1/CXCR3-IN-1 inhibits the replication of four dengue virus serotypes in host cells and significantly reduces viral load^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sirt1/CXCR3-IN-1 (Compound 7D) reduces dengue viral load in infected AG129 mice, demonstrating in vivo antiviral efficacy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 536.62
Formula C₃₂H₃₂N₄O₄
SMILES

OC([C@H](NC(C1=CC(N=C(C2=CC=C(OC)C=C2)N3C4CCCCC4)=C3C=C1)=O)CC5=CNC6=C5C=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lokhande, et al. (2026). Harnessing the structural determinants amenable for polypharmacological behavior of 7D against Sirt1 and CXCR3. iScience.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Sirt1/CXCR3-IN-1

All Sirtuin Isoforms

All CXCR Isoforms