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Daporinad hydrochloride

(Synonyms: FK866 hydrochloride; APO866 hydrochloride)
67 Cited Publications
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Based on 67 publication(s) in Google Scholar

Daporinad (FK866) hydrochloride is a non-competitive inhibitor of nicotinamide phosphoribosyltransferase (Nampt), with a Ki value of 0.3 nM. Daporinad hydrochloride depletes NAD+ and ATP levels, inhibits mTORC1 and MAPK/ERK pathways, and activates TFEB to induce autophagy. Daporinad hydrochloride causes the depletion of the endoplasmic reticulum Ca²⁺ pool, ultimately weakening the mitogen-induced Ca²⁺ signal and the activation and function of T cells. Daporinad hydrochloride induces cell cycle arrest and apoptosis, and inhibits cell proliferation. Daporinad hydrochloride can be used for the study of myeloma, liver cancer, and immunosuppression.

For research use only. We do not sell to patients.

  • CAS No.: 2727965-45-7
  • Formula: C24H30ClN3O2
  • Molecular Weight:427.97
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Daporinad hydrochloride Chemical Structure
    Daporinad hydrochloride Chemical Structure
  • Experimental Validation Results for Daporinad hydrochloride
  • Experimental Validation Results for Daporinad hydrochloride
  • Experimental Validation Results for Daporinad hydrochloride
  • Experimental Validation Results for Daporinad hydrochloride
  • Experimental Validation Results for Daporinad hydrochloride
CAS No.: 2727965-45-7
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Daporinad hydrochloride Chemical Structure
    Daporinad hydrochloride Chemical Structure
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    Daporinad hydrochloride purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 29:S2090-1232(25)01020-3. [Abstract]

    Customer Validation
     Representative ocular fundus images and clinical scores from the Normal, EAU, and NAMPTi (FK866; 10 mg/kg; ip; daily for 14 days ) groups at day 14 post-immunization. White arrows highlight inflammatory infiltrates and vascular abnormalities. B. Representative histopathological images and histological scores from the Normal, EAU and NAMPTi groups at day 14 post-immunization. Black arrows highlight inflammatory cell infiltration, retinal detachment, and retinal folding.

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    Daporinad hydrochloride purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 29:S2090-1232(25)01020-3. [Abstract]

    Customer Validation
     NAMPT inhibition ameliorates EAU by modulating the Teff/Treg balance and suppressing Hif1a in CD4+ T cells in vivo. A-B. Frequencies of CD4+IL 17A+ (Th17) cells and CD4+ IFN γ+(Th1) cells in both CDLNs (A) and spleen (B) of EAU and NAMPTi (FK866; 10 mg/kg; ip; daily for 14 days ) treated EAU mice on day 14 post-immunization. C-D. Frequencies of CD4+-CD25+Foxp3+ (Treg) cells in both CDLNs (C) and spleen (D).

  • 1/16

    Daporinad hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Metab. 2024 Aug 6;36(8):1806-1822.e11. [Abstract]

    Customer Validation
     Flow cytometry analysis of M1 (CD86) and M2 (CD206) markers in human peripheral blood-derived macrophages or NAMPT-overexpressing (oxNAMPT) macrophages both treated with FK866 (10 nM, 48 h).

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    Daporinad hydrochloride purchased from MedChemExpress. Usage Cited in: J Cell Physiol. 2019 Apr;234(4):4385-4395. [Abstract]

    Customer Validation
     SW620 and HCT116 cells are seeded into a six-well plate for 72 hr, followed by treatment with different concentrations (100 nM and 10 μM) of FK866 for 24 hr.

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    Daporinad hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2017 Oct;16(4):5121-5128. [Abstract]

    Customer Validation
     Effects of Emodin, FK866 and DEX on PMN apoptosis in SAP rats. Protein expression levels of Fas, FasL, Bax, cleaved caspase 3 and Bcl xL are detected by western blotting. β actin served as an internal control. Data are presented as the mean±standard deviation.

  • Daporinad hydrochloride