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Art. -Nr.: HY-110319

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(E/Z)-Daporinad hydrochloride

(Synonyms: (E/Z)-FK866 hydrochloride; (E/Z)-APO866 hydrochloride)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

(E/Z)-Daporinad hydrochloride ((E/Z)-FK866 hydrochloride) is a potent inhibitor of nicotinamide phosphoribose transferase (NAMPT). (E/Z)-Daporinad hydrochloride induces apoptosis by specifically inhibiting NAMPT to gradually deplete intracellular NAD⁺. (E/Z)-Daporinad hydrochloride can be used in the study of cancer biology and inflammatory diseases.

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CAS. Nr.: 1785666-54-7
Formel: C₂₄H₃₀ClN₃O₂
Molecular Weight:427.97

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

(E/Z)-Daporinad hydrochloride Chemical Structure

CAS. Nr.: 1785666-54-7

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Chemical Information

CAS. Nr. 1785666-54-7
Molecular Weight 427.97
Formel C₂₄H₃₀ClN₃O₂
SMILES

O=C(N1CCC(CC1)CCCCNC(/C=C/C2=CN=CC=C2)=O)C3=CC=CC=C3.Cl
Synonyms

(E/Z)-FK866 hydrochloride; (E/Z)-APO866 hydrochloride
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Signal Transduct Target Ther

High mtDNA content identifies oxidative phosphorylation-driven acute myeloid leukemias and represents a therapeutic vulnerability. [Abstract]

2025 Jul 14;10(1):222. PMID: 40653487

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Qu S D, Liu G X. Daporinad in vitro metabolite profiling via rat, dog, monkey and human liver microsomes by liquid chromatography/quadrupole‐orbitrap mass spectrometry[J]. Rapid Communications in Mass Spectrometry, 2021, 35(18): e9150. [Content Brief]

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Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

(E/Z)-Daporinad hydrochloride

1 Cited Publications

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(E/Z)-Daporinad hydrochloride

Publications Citing Use of MedChemExpress (MCE) (E/Z)-Daporinad hydrochloride

Biologische Aktivität

Chemical Information

Publications (1)

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(E/Z)-Daporinad hydrochloride Related Classifications

HY-110319 Related Classifications