923255-75-8
923255-75-8
Chemical Structure
INN-312
- CAS No.: 923255-75-8
- Formula:C14H13NO3
- Molecular Weight:243.26
IUPAC Name: 5-methoxy-2-(pyridin-3-ylmethoxy)benzaldehyde
InChIKey: GXQNKVDAAINMNE-UHFFFAOYSA-N
SMILES: O=CC1=CC(OC)=CC=C1OCC=2C=NC=CC2
Biological Activity: INN-312 is a sickle hemoglobin (Hb S) inhibitor capable of penetrating red blood cell membranes. INN-312 inhibits sickling of sickle red blood cells under hypoxic conditions, increases the oxygen affinity of Hb, and moderately improves the solubility of deoxygenated Hb S. INN-312 can be used in research related to sickle cell disease[1][2].
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INN-312 | INN-312 is a sickle hemoglobin (Hb S) inhibitor capable of penetrating red blood cell membranes. INN-312 inhibits sickling of sickle red blood cells under hypoxic conditions, increases the oxygen affinity of Hb, and moderately improves the solubility of deoxygenated Hb S. INN-312 can be used in research related to sickle cell disease. | |||||||||||||||||||||
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References
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[1]. Abdulmalik, O. Y., et al. (2005). In Vitro Antisickling Effects of Novel Pyridyl Derivatives with Enhanced Potency. Blood, 106(11), 2347.
- [2]. Abdulmalik O, et al. VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions. Scientific reports. 2020 Nov 20;10(1):20277. [Content Brief]
