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Cat. No.: HY-W305227

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INN-312

INN-312 is a sickle hemoglobin (Hb S) inhibitor capable of penetrating red blood cell membranes. INN-312 inhibits sickling of sickle red blood cells under hypoxic conditions, increases the oxygen affinity of Hb, and moderately improves the solubility of deoxygenated Hb S. INN-312 can be used in research related to sickle cell disease.

For research use only. We do not sell to patients.

CAS No.: 923255-75-8
Formula: C₁₄H₁₃NO₃
Molecular Weight:243.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

INN-312 Chemical Structure

CAS No.: 923255-75-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

INN-312 (0.5-2 mM) dose-dependently inhibits sickling of sickle erythrocytes (SS cells) under hypoxic conditions at 37°C, with 81% inhibition at 2 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

INN-312 (50-150 mg/kg; i.p.; single dose) produces dose-dependent increases in AUC_0-t and C_max in transgenic sickle mice, with consistent pharmacokinetic parameters across doses, and strongly shifts hemoglobin OEC leftward^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Transgenic sickle mice^[1]
Dosage:

50 mg/kg; 100 mg/kg; 150 mg/kg
Administration:

i.p.; single dose
Result:

Produced AUC values of 314 µg/mL/min, 648 µg/mL/min, and 1044 µg/mL/min for 50, 100, and 150 mg/kg doses, respectively.
Showed terminal half-life of 0.75 h, peak concentration time of 0.5 h, and mean resident time of 1.2 h, consistent across all dosage groups.
Increased maximum plasma concentration in a dose-dependent manner.
Shifted hemoglobin oxygen equilibrium curve toward the left more strongly than various previously reported compounds.

Chemical Information

CAS No. 923255-75-8
Molecular Weight 243.26
Formula C₁₄H₁₃NO₃
SMILES

O=CC1=CC(OC)=CC=C1OCC=2C=NC=CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Abdulmalik, O. Y., et al. (2005). In Vitro Antisickling Effects of Novel Pyridyl Derivatives with Enhanced Potency. Blood, 106(11), 2347.

[2]. Abdulmalik O, et al. VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions. Scientific reports. 2020 Nov 20;10(1):20277. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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