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TLR7 agonist 20

TLR7 agonist 20 is a selective Toll-like receptor 7 (TLR7) agonist with an EC₅₀ of 0.22 μM. TLR7 agonist 20, as an immunostimulant and vaccine adjuvant, enhances the production of anti-spike protein antibodies, increases IgG2b and IgG2c levels, and thereby drives Th1-type immune responses in mice. TLR7 agonist 20 can be used in studies related to non-inflammatory potent vaccine adjuvants.

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CAS No.: 3029695-00-6
화학식: C₂₂H₂₄N₄O
분자량:360.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

TLR7 agonist 20 Chemical Structure

CAS No.: 3029695-00-6

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Sample (0.1mg)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

TLR7

0.22 μM (EC₅₀)

All Toll-like Receptor (TLR) Isoforms :

In Vitro

TLR7 agonist 20 (Compound 23) (≤ 10 μM) shows no cytotoxicity in the NCI60 human cancer cell line panel^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TLR7 agonist 20 (Compound 23) (10 μg; i.m.; 2 doses) acts as a potent vaccine adjuvant in mice, inducing a strong Th1 response when administered alone with SARS-CoV-2 spike antigen and enhancing balanced Th1/Th2 responses when co-formulated with alum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (female, 6-8 weeks old)^[1]
Dosage:

10 μg (co-formulated with SARS-CoV-2 spike antigen); 10 μg (co-formulated with SARS-CoV-2 spike antigen and 50 μg alum)
Administration:

i.m.; administered at week 0 and week 2
Result:

Induced significantly higher anti-spike IgG2b (OD₄₅₀ ≈ 0.9) and IgG2c (OD₄₅₀ ≈ 0.8) levels compared to spike antigen alone.
Induced significantly higher anti-spike IgG (OD₄₅₀ ≈ 2.5), IgG1 (OD₄₅₀ ≈ 3.0), IgG2b (OD₄₅₀ ≈ 0.7), and IgG2c (OD₄₅₀ ≈ 0.8) levels compared to spike antigen alone when co-formulated with alum and spike antigen.

Chemical Information

CAS No. 3029695-00-6
분자량 360.45
화학식 C₂₂H₂₄N₄O
SMILES

CCCCC1=NC2=C(C3=CC=CC=C3N=C2N)N1CC4=CC=C(C=C4)CO
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kaushik D, et al. Structure-Activity Relationships toward the Identification of a High-Potency Selective Human Toll-like Receptor-7 Agonist. J Med Chem. 2024 May 23;67(10):8346-8360. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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