2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR7 agonist 20

TLR7 agonist 20 is a selective Toll-like receptor 7 (TLR7) agonist with an EC50 of 0.22 μM. TLR7 agonist 20, as an immunostimulant and vaccine adjuvant, enhances the production of anti-spike protein antibodies, increases IgG2b and IgG2c levels, and thereby drives Th1-type immune responses in mice. TLR7 agonist 20 can be used in studies related to non-inflammatory potent vaccine adjuvants.

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TLR7 agonist 20

TLR7 agonist 20 Chemical Structure

CAS No. : 3029695-00-6

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TLR7 agonist 20 Related Antibodies

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Description

TLR7 agonist 20 is a selective Toll-like receptor 7 (TLR7) agonist with an EC50 of 0.22 μM. TLR7 agonist 20, as an immunostimulant and vaccine adjuvant, enhances the production of anti-spike protein antibodies, increases IgG2b and IgG2c levels, and thereby drives Th1-type immune responses in mice. TLR7 agonist 20 can be used in studies related to non-inflammatory potent vaccine adjuvants[1].

IC50 & Target[1]

TLR7

0.22 μM (EC50)

In Vitro

TLR7 agonist 20 (Compound 23) (≤ 10 μM) shows no cytotoxicity in the NCI60 human cancer cell line panel[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TLR7 agonist 20 Related Antibodies
In Vivo

TLR7 agonist 20 (Compound 23) (10 μg; i.m.; 2 doses) acts as a potent vaccine adjuvant in mice, inducing a strong Th1 response when administered alone with SARS-CoV-2 spike antigen and enhancing balanced Th1/Th2 responses when co-formulated with alum[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (female, 6-8 weeks old)[1]
Dosage: 10 μg (co-formulated with SARS-CoV-2 spike antigen); 10 μg (co-formulated with SARS-CoV-2 spike antigen and 50 μg alum)
Administration: i.m.; administered at week 0 and week 2
Result: Induced significantly higher anti-spike IgG2b (OD450 ≈ 0.9) and IgG2c (OD450 ≈ 0.8) levels compared to spike antigen alone.
Induced significantly higher anti-spike IgG (OD450 ≈ 2.5), IgG1 (OD450 ≈ 3.0), IgG2b (OD450 ≈ 0.7), and IgG2c (OD450 ≈ 0.8) levels compared to spike antigen alone when co-formulated with alum and spike antigen.
Molecular Weight

360.45

Formula

C22H24N4O
CAS No.
SMILES

CCCCC1=NC2=C(C3=CC=CC=C3N=C2N)N1CC4=CC=C(C=C4)CO
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TLR7 agonist 20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7 agonist 203029695-00-6Toll-like Receptor (TLR)adjuvant activityIMDQimidazoquinolinespike proteinInhibitorinhibitorinhibit

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