TLR7 agonist 20 hydrochloride
Based on 1 Customer Validation
TLR7 agonist 20 hydrochloride is a selective Toll-like receptor 7 (TLR7) agonist with an EC50 of 0.22 μM. TLR7 agonist 20 hydrochloride, as an immunostimulant and vaccine adjuvant, enhances the production of anti-spike protein antibodies, increases IgG2b and IgG2c levels, and thereby drives Th1-type immune responses in mice. TLR7 agonist 20 hydrochloride can be used in studies related to non-inflammatory potent vaccine adjuvants.
For research use only. We do not sell to patients.
- Purity: 99.86%
- Formula: C22H25ClN4O
- Molecular Weight:396.91
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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TLR7 0.22 μM (EC50) |
TLR7 agonist 20 (Compound 23) (≤ 10 μM) hydrochloride shows no cytotoxicity in the NCI60 human cancer cell line panel[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (female, 6-8 weeks old)[1]
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Dosage:10 μg (co-formulated with SARS-CoV-2 spike antigen); 10 μg (co-formulated with SARS-CoV-2 spike antigen and 50 μg alum)
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Administration:i.m.; administered at week 0 and week 2
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Result:Induced significantly higher anti-spike IgG2b (OD450 ≈ 0.9) and IgG2c (OD450 ≈ 0.8) levels compared to spike antigen alone.
Induced significantly higher anti-spike IgG (OD450 ≈ 2.5), IgG1 (OD450 ≈ 3.0), IgG2b (OD450 ≈ 0.7), and IgG2c (OD450 ≈ 0.8) levels compared to spike antigen alone when co-formulated with alum and spike antigen.
Chemical Information
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Appearance Solid
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Molecular Weight 396.91
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Formula C22H25ClN4O
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Color White to off-white
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SMILES
CCCCC1=NC2=C(C3=CC=CC=C3N=C2N)N1CC4=CC=C(C=C4)CO.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 10 mg/mL (25.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5195 mL | 12.5973 mL | 25.1946 mL | 62.9866 mL |
| 5 mM | 0.5039 mL | 2.5195 mL | 5.0389 mL | 12.5973 mL | |
| 10 mM | 0.2519 mL | 1.2597 mL | 2.5195 mL | 6.2987 mL | |
| 15 mM | 0.1680 mL | 0.8398 mL | 1.6796 mL | 4.1991 mL | |
| 20 mM | 0.1260 mL | 0.6299 mL | 1.2597 mL | 3.1493 mL | |
| 25 mM | 0.1008 mL | 0.5039 mL | 1.0078 mL | 2.5195 mL |
TLR7 agonist 20 hydrochloride Related Classifications
HY-158694A Related Classifications
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