1. Cell Cycle/DNA Damage
  2. Sirtuin
  3. MC3482


Cat. No.: HY-112587 Purity: 99.22%
Handling Instructions

MC3482 is a specific sirtuin5 (SIRT5) inhibitor.

For research use only. We do not sell to patients.

MC3482 Chemical Structure

MC3482 Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 885 In-stock
Estimated Time of Arrival: December 31
5 mg USD 650 In-stock
Estimated Time of Arrival: December 31
10 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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MC3482 is a specific sirtuin5 (SIRT5) inhibitor.

IC50 & Target


In Vitro

MC3482 inhibits sirtuin5. 50 μM MC3482 inhibits SIRT5 desuccinylating activity without affecting SIRT5 intracellular expression levels. Autophagy and mitophagy increase in SIRT5-silenced cells and in WT cells treated with MC3482 and decrease in SIRT5-overexpressing cells[1].

Molecular Weight





O=C(N[[email protected]](C(NC1=CC=CC=C1)=O)CCCCNC(CC[[email protected]@H](C(O)=O)NC(OCC2=CC=CC=C2)=O)=O)OCC3=CC=CC=C3


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 130 mg/mL (210.12 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6163 mL 8.0817 mL 16.1634 mL
5 mM 0.3233 mL 1.6163 mL 3.2327 mL
10 mM 0.1616 mL 0.8082 mL 1.6163 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (3.51 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (3.51 mM); Clear solution

*All of the co-solvents are provided by MCE.
Cell Assay

MDA-MB-231 and C2C12 cells are treated with 50μM of SIRT5 inhibitor MC3482 for 24 h. Ammonia levels are measured in the culture medium every other day[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: 99.22%

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