1. Cell Cycle/DNA Damage
    Epigenetics
  2. Sirtuin

MC3482 

Cat. No.: HY-112587
Handling Instructions

MC3482 is a specific sirtuin5 (SIRT5) inhibitor.

For research use only. We do not sell to patients.

MC3482 Chemical Structure

MC3482 Chemical Structure

Size Stock
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Customer Review

View All Sirtuin Isoform Specific Products:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

MC3482 is a specific sirtuin5 (SIRT5) inhibitor.

IC50 & Target

SIRT5[1]

In Vitro

MC3482 inhibits sirtuin5. 50 μM MC3482 inhibits SIRT5 desuccinylating activity without affecting SIRT5 intracellular expression levels. Autophagy and mitophagy increase in SIRT5-silenced cells and in WT cells treated with MC3482 and decrease in SIRT5-overexpressing cells[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6163 mL 8.0817 mL 16.1634 mL
5 mM 0.3233 mL 1.6163 mL 3.2327 mL
10 mM 0.1616 mL 0.8082 mL 1.6163 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

MDA-MB-231 and C2C12 cells are treated with 50μM of SIRT5 inhibitor MC3482 for 24 h. Ammonia levels are measured in the culture medium every other day[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

618.68

Formula

C₃₃H₃₈N₄O₈

SMILES

O=C(N[[email protected]](C(NC1=CC=CC=C1)=O)CCCCNC(CC[[email protected]@H](C(O)=O)NC(OCC2=CC=CC=C2)=O)=O)OCC3=CC=CC=C3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
MC3482
Cat. No.:
HY-112587
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MC3482

Cat. No.: HY-112587