URAT1/GLUT9-IN-2
URAT1/GLUT9-IN-2 is a selective, orally active URAT1/GLUT9 inhibitor, with an IC50 of 2.81 μM against URAT1 and an IC50 of 12.53 μM against GLUT9. URAT1/GLUT9-IN-2 reduces serum uric acid levels and protects renal function. URAT1/GLUT9-IN-2 can be used in research related to hyperuricemia and hyperuricemic nephropathy.
For research use only. We do not sell to patients.
- CAS No.: 3051509-32-8
- Formula: C25H21N3O5S
- Molecular Weight:475.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GLUT9 12.53 μM (IC50) |
URAT1 2.81 μM (IC50) |
URAT1/GLUT9-IN-2 (Compound 42) (30 min) potently inhibits URAT1 in HEK293T cells expressing hURAT1, with an IC50 of 2.81 μM[1].
URAT1/GLUT9-IN-2 inhibits GLUT9 in HEK293T cells expressing hGLUT9, with an IC50 value of 12.53 μM[1].
URAT1/GLUT9-IN-2 (10 μM; 15 min) shows no significant xanthine oxidase (XOD) inhibitory activity, with an inhibition rate of only 14.43% at a concentration of 10 μM[1].
URAT1/GLUT9-IN-2 (30 min) inhibits OAT1-mediated transport in HEK293T cells expressing hOAT1, with an IC50 of 7.83 μM. Compared with ZS-24, it exhibits weaker off-target activity and improved selectivity[1].
URAT1/GLUT9-IN-2 (0-50 μM; 3-20 min) does not inhibit CYP1A2, CYP2C19 or CYP2D6, but moderately inhibits CYP2C9 and CYP3A4M, with IC50 values of 1.12 μM and 1.38 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
URAT1/GLUT9-IN-2 (2 mg/kg; p.o.; single administration) exhibits potent hypouricemic activity in acute hyperuricemic SD rats, reducing serum uric acid (SUA) by 89.25% at an oral dose of 2 mg/kg[1].
URAT1/GLUT9-IN-2 (2 mg/kg; i.p.; once daily; for 7 consecutive days) reduces serum uric acid levels and protects renal function in hyperuricemic nephropathy KM mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Kunming (KM) mice (male)[1]
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Dosage:1 mg/kg; 0.5 mg/kg
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Administration:p.o.; single dose
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Result:Reduced SUA with a DR of 80.25% at 1 mg/kg.
Reduced SUA with a DR of 11.98% at 0.5 mg/kg.
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Animal Model:Sprague-Dawley (SD) rats[1]
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Dosage:2 mg/kg
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Administration:p.o.; single dose
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Result:Reduced SUA with a DR of 89.25%.
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Animal Model:Kunming (KM) mice (male)[1]
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Dosage:2 mg/kg
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Administration:i.p.; daily; 7 days
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Result:Significantly reduced SUA levels.
Decreased BUN and CRE levels.
Reduced kidney mass and kidney/body weight ratio.
Prevented renal edema/whitening compared to the model group.
Chemical Information
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CAS No. 3051509-32-8
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Molecular Weight 475.52
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Formula C25H21N3O5S
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SMILES
O=C(NS(=O)(C1=CC=CC([N+]([O-])=O)=C1)=O)C2=CC=CN2CC3=C4C=CC=CC4=C(C=C3)C5CC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
URAT1/GLUT9-IN-2 Related Classifications
HY-183543 Related Classifications
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