Xininurad
Based on 1 Customer Validation
Xininurad is a potent orally active URAT1 inhibitor with an IC50 of 7.17 nM. Xininurad inhibits URAT1 activity to reduce serum uric acid levels and increase urinary uric acid excretion. Xininurad can be used for the research of hyperuricemia and gout.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.59%
- No. CAS: 2365178-28-3
- Fòrmula: C15H10Br2FN3O2
- Peso molecular:443.07
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-15258
LesinuradURAT1 Inhibitor -
HY-16733
VerinuradURAT1 Inhibitor -
HY-W052011
RuzinuradURAT1 Inhibitor -
HY-147300
PuliginuradURAT Inhibitor -
HY-16733R
Verinurad (Standard)URAT1 Inhibitor -
HY-153971
URAT1 inhibitor 8URAT1 Inhibitor -
HY-15258A
Lesinurad sodiumURAT1/OAT4 Inhibitor -
HY-114309
URAT1 inhibitor 1URAT1 Inhibitor -
HY-153969
URAT1 inhibitor 6URAT1 Inhibitor -
HY-151432
URAT1 inhibitor 3URAT1 Inhibitor -
HY-153972
URAT1&XO inhibitor 2URAT1&XO Inhibitor
Actividad biológica
Descripciòn
IC50 & Target
URAT[1]
In Vitro
Xininurad inhibits CYP2C9 enzymatic activity and weakly inhibits CYP2C8 enzymatic activity[1].
Xininurad does not induce the enzymatic activity or mRNA expression levels of CYP1A2, CYP2B6 or CYP3A4[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 2365178-28-3
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Appearance Solid
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Peso molecular 443.07
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Fòrmula C15H10Br2FN3O2
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Color Off-white to light yellow
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SMILES
O=C(C1=C(CC)N=C2N=CC(F)=CN21)C3=CC(Br)=C(C(Br)=C3)O
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Synonyms
XNW3009
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvente y solubilidad
In Vitro:
DMSO : 7.14 mg/mL (16.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2570 mL | 11.2849 mL | 22.5698 mL | 56.4245 mL |
| 5 mM | 0.4514 mL | 2.2570 mL | 4.5140 mL | 11.2849 mL | |
| 10 mM | 0.2257 mL | 1.1285 mL | 2.2570 mL | 5.6424 mL | |
| 15 mM | 0.1505 mL | 0.7523 mL | 1.5047 mL | 3.7616 mL |
Xininurad Related Classifications
HY-147422 Related Classifications
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