62265-68-3
Chemical Structure
Quinfamide
Synonym(s): WIN-40014
- CAS No.: 62265-68-3
- Formula:C16H13Cl2NO4
- Molecular Weight:354.18
IUPAC Name: 1-(2,2-dichloroacetyl)-1,2,3,4-tetrahydroquinolin-6-yl furan-2-carboxylate
InChIKey: SBJGFIXQRZOVTO-UHFFFAOYSA-N
SMILES: O=C(OC1=CC2=C(C=C1)N(CCC2)C(C(Cl)Cl)=O)C3=CC=CO3
Biological Activity: Quinfamide (WIN-40014) is an orally active class of dichloroacetyl derivative with significant anti-intestinal protozoan, particularly mmoeba histolytica activity. Quinfamide exhibits antiamoebic activity under solvent-free conditions with an IC50 of 28.15 μg/mL in a suspension condition. Quinfamide particles are actively engulfed by the amoebas, then cells are affected, and finally, amoebas are killed and lysed, and this process directly relies on the physical intake of the drug particles. Quinfamide can be used in the research of tropical parasitic infections such as amoebiasis and helminthiasis[1][2][3].
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Quinfamide | 99.69% | Quinfamide (WIN-40014) is an orally active class of dichloroacetyl derivative with significant anti-intestinal protozoan, particularly mmoeba histolytica activity. Quinfamide exhibits antiamoebic activity under solvent-free conditions with an IC50 of 28.15 μg/mL in a suspension condition. Quinfamide particles are actively engulfed by the amoebas, then cells are affected, and finally, amoebas are killed and lysed, and this process directly relies on the physical intake of the drug particles. Quinfamide can be used in the research of tropical parasitic infections such as amoebiasis and helminthiasis. | ||||||||||||||||||||
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- [1]. Itzcoatl Aquino, et al. In vivo anticoccidial activity of quinfamide in broilers: a preliminary report. 2016 Mar
- [2]. Slighter RG, et al. Activity of quinfamide against natural infections of Entamoeba criceti in hamsters: a new potent agent for intestinal amoebiasis. Parasitology. 1980 Aug;81(1):157-68. [Content Brief]
- [3]. Anaya-Velázquez F, Morales-Fuentes L. Phagocytosis of quinfamide particles by Entamoeba histolytica. Arch Med Res. 2000 Jul-Aug;31(4 Suppl):S10-1. [Content Brief]
Keywords
