1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Chloroxine

Chloroxine 

Cat. No.: HY-B0295 Purity: 99.38%
Handling Instructions

Chloroxine is one of the important 8-hydroxyquinoline derivative. Chloroxine has effective antibacterial, antifungal, antiprotozoal and antiamoebic activities, especially used in treating the intestinal amebiasis. Chloroxine is also used in the treatment of dandruff and seborrheic dermatitis of the scalp.

For research use only. We do not sell to patients.

Chloroxine Chemical Structure

Chloroxine Chemical Structure

CAS No. : 773-76-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 106 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Description

Chloroxine is one of the important 8-hydroxyquinoline derivative. Chloroxine has effective antibacterial, antifungal, antiprotozoal and antiamoebic activities, especially used in treating the intestinal amebiasis. Chloroxine is also used in the treatment of dandruff and seborrheic dermatitis of the scalp[1][2].

IC50 & Target

Bacterial[1]

In Vitro

By using the Jouyban-Acree model, the Chloroxine solubility is well correlated obtaining RAD values lower than 3.64% and RMSD values lower than 8.82 × 10−6. Chloroxine is preferentially solvated by water for the studied mixtures in water-rich compositions; while within intermediate and co-solvent-rich compositions, Chloroxine is preferentially solvated by DMSO (DMF, NMP or 1,4-dioxane) in DMSO (DMF, NMP or 1,4-dioxane) + water mixtures. It is shown that the change in solvent-solvent interaction energy accounted by cavity term governed the solubility variation of Chloroxine in all aqueous mixtures[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

214.05

Formula

C₉H₅Cl₂NO

CAS No.
SMILES

OC1=C2N=CC=CC2=C(Cl)C=C1Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (155.71 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6718 mL 23.3590 mL 46.7181 mL
5 mM 0.9344 mL 4.6718 mL 9.3436 mL
10 mM 0.4672 mL 2.3359 mL 4.6718 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (11.68 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (11.68 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

ChloroxineBacterialAntibioticInhibitorinhibitorinhibit

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Chloroxine
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HY-B0295
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