1. Anti-infection
    Cell Cycle/DNA Damage
  2. Bacterial
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  3. Cloxiquine

Cloxiquine (Synonyms: 5-Chloro-8-quinolinol)

Cat. No.: HY-B0963 Purity: ≥98.0%
Handling Instructions

Cloxiquine (5-Chloro-8-quinolinol) is an antibacterial, antifungal and antiamoebic agent. Cloxiquine can be used for the research of tuberculosis and dermatoses. Cloxiquine suppresses the growth and metastasis of melanoma cells through activation of PPARγ.

For research use only. We do not sell to patients.

Cloxiquine Chemical Structure

Cloxiquine Chemical Structure

CAS No. : 130-16-5

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
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5 g USD 60 In-stock
Estimated Time of Arrival: December 31
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Description

Cloxiquine (5-Chloro-8-quinolinol) is an antibacterial, antifungal and antiamoebic agent. Cloxiquine can be used for the research of tuberculosis and dermatoses. Cloxiquine suppresses the growth and metastasis of melanoma cells through activation of PPARγ[1][2].

In Vitro

Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis[3].
Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner[2].
Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells[2].
Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model[2].
Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

179.60

Formula

C₉H₆ClNO

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (556.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5679 mL 27.8396 mL 55.6793 mL
5 mM 1.1136 mL 5.5679 mL 11.1359 mL
10 mM 0.5568 mL 2.7840 mL 5.5679 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (13.92 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (13.92 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Cloxiquine
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