Cloxiquine  (Synonyms: 5-Chloro-8-quinolinol)

Cloxiquine (5-Chloro-8-quinolinol) is an antibacterial, antifungal and antiamoebic agent. Cloxiquine can be used for the research of tuberculosis and dermatoses. Cloxiquine suppresses the growth and metastasis of melanoma cells through activation of PPARγ^[1][2].

Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis^[3].
Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner^[2].
Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells^[2].
Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model^[2].
Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

179.60

Solid

C₉H₆ClNO

130-16-5

OC1=C2N=CC=CC2=C(Cl)C=C1

Room temperature in continental US; may vary elsewhere.

• [1]. Latosińska JN, et al. Supramolecular synthon pattern in solid clioquinol and cloxiquine (APIs of antibacterial, antifungal, antiaging and antituberculosis drugs) studied by ³⁵Cl NQR, ¹H-¹⁷O and ¹H-¹⁴N NQDR and DFT/QTAIM. J Mol Model. 2011 Jul;17(7):1781-800.  [Content Brief]

  [2]. Zhang W, et, al. Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ. Cell Death Dis. 2019 May 28;10(6):404.  [Content Brief]

  [3]. Hongmanee P, et, al. In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2007 Mar;51(3):1105-6.  [Content Brief]