7542-37-2
Chemical Structure
Paromomycin
Synonym(s): Aminosidine
- CAS No.: 7542-37-2
- Formula:C23H45N5O14
- Molecular Weight:615.63
IUPAC Name: (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol
InChIKey: UOZODPSAJZTQNH-LSWIJEOBSA-N
SMILES: O[C@H]([C@@H]([C@H](O1)CO)O[C@H]2O[C@H]([C@H]([C@@H]([C@H]2N)O)O)CN)[C@@H]1O[C@H]([C@H]([C@@H](C[C@@H]3N)N)O)[C@@H]3O[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4N)O)O)CO
Biological Activity: Paromomycin (Aminosidine) is an orally active broad-spectrum aminoglycoside aminocyclitol. Paromomycin is produced by Streptomyces riomosus var. Paromomycinus. Paromomycin binding induces local conformational changes in the 16S rRNA A-site. Paromomycin exhibits inhibitory activity against C. parvum. Paromomycin can be used in research related to leishmaniasis, amoebiasis and cryptosporidiosis[1][2][3].
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Paromomycin | Paromomycin (Aminosidine) is an orally active broad-spectrum aminoglycoside aminocyclitol. Paromomycin is produced by Streptomyces riomosus var. Paromomycinus. Paromomycin binding induces local conformational changes in the 16S rRNA A-site. Paromomycin exhibits inhibitory activity against C. parvum. Paromomycin can be used in research related to leishmaniasis, amoebiasis and cryptosporidiosis. | |||||||||||||||||||||
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References
- [1]. Sundar S, et al. Paromomycin in the treatment of leishmaniasis. Expert Opin Investig Drugs. 2008;17(5):787-794. [Content Brief]
- [2]. Fourmy D, et al. Paromomycin binding induces a local conformational change in the A-site of 16 S rRNA. J Mol Biol. 1998;277(2):333-345. [Content Brief]
- [3]. Healey MC, et al. Therapeutic efficacy of paromomycin in immunosuppressed adult mice infected with Cryptosporidium parvum. J Parasitol. 1995;81(1):114-116. [Content Brief]
