Aristolactam A II
Based on 1 Customer Validation
Aristolactam A II (Aristololactam A II) is a weak COX inhibitor with cytotoxic and anti-plasmodial activities. Aristolactam A II exhibits inhibitory activity against Chloroquine (HY-17589A)-sensitive strains, and exerts its inhibitory effect on Plasmodium falciparum growth by inducing cell membrane damage marked by LDH release. Aristolactam A II can be applied to the research of malaria-related mechanisms.
For research use only. We do not sell to patients.
- Purity: 96.74%
- CAS No.: 53948-07-5
- Formula: C16H11NO3
- Molecular Weight:265.26
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All Parasite Isoforms
More
Biological Activity
|
Plasmodium falciparum sporozoites |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| B-cell | IC50 |
>100 μM
Compound: 13
|
Inhibition of LPS-induced BALB/c mouse B cell proliferation
Inhibition of LPS-induced BALB/c mouse B cell proliferation
|
[PMID: 17081761] |
| Col2 | ED50 |
>5 μg/mL
Compound: 10
|
Cytotoxicity against human Col2 cells by SRB assay
Cytotoxicity against human Col2 cells by SRB assay
|
[PMID: 17190450] |
| KB | ED50 |
>5 μg/mL
Compound: 10
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 17190450] |
| KB | ED50 |
2.1 μg/mL
Compound: 4
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 3437282] |
| KB | IC50 |
>37 μM
Compound: 7
|
Cytotoxicity against human KB cells after 72 hrs by neutral red staining
Cytotoxicity against human KB cells after 72 hrs by neutral red staining
|
[PMID: 19053513] |
| Lu1 | ED50 |
>5 μg/mL
Compound: 10
|
Cytotoxicity against human Lu1 cells by SRB assay
Cytotoxicity against human Lu1 cells by SRB assay
|
[PMID: 17190450] |
| P388 | ED50 |
2.7 μg/mL
Compound: 10
|
Cytotoxicity against mouse P388 cells by SRB assay
Cytotoxicity against mouse P388 cells by SRB assay
|
[PMID: 17190450] |
| P388 | ED50 |
3.2 μg/mL
Compound: 4
|
Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
|
[PMID: 3437282] |
| T-cell | IC50 |
>100 μM
Compound: 13
|
Inhibition of ConA-induced BALB/c mouse T cell proliferation
Inhibition of ConA-induced BALB/c mouse T cell proliferation
|
[PMID: 17081761] |
Aristolactam A II inhibits the growth of chloroquine-sensitive Plasmodium falciparum strain 3D7, with an IC50 of 28 μM at 72 h[1].
Aristolactam A II (2.5-160 mg/mL; 24-72 h) induces time- and dose-dependent cytotoxicity in HK-2 cells, with IC50 values of 97.22 mg/mL, 74.15 mg/mL, and 44.06 mg/mL at 24 h, 48 h, and 72 h, respectively[2].
Aristolactam A II (2.5-160 mg/mL; 24 h) causes concentration-dependent cell membrane damage to HK-2 cells, which can be detected by increased LDH release[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:human proximal tubular epithelial HK-2 cells
-
Concentration:2.5-160 mg/mL
-
Incubation Time:24 h
-
Result:Caused a significant concentration-dependent increase in LDH release (p < 0.05), indicating cell membrane damage.
Showed a higher LDH release rate than cepharanone B, indicating greater cell membrane damage and stronger cytotoxicity relative to that compound.
Chemical Information
-
CAS No. 53948-07-5
-
Appearance Solid
-
Molecular Weight 265.26
-
Formula C16H11NO3
-
Color Light yellow to yellow
-
SMILES
O=C1NC2=C3C1=CC(O)=C(OC)C3=C4C(C=CC=C4)=C2
-
Synonyms
Aristololactam A II
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 11 mg/mL (41.47 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (277 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7699 mL | 18.8494 mL | 37.6989 mL | 94.2472 mL |
| 5 mM | 0.7540 mL | 3.7699 mL | 7.5398 mL | 18.8494 mL | |
| 10 mM | 0.3770 mL | 1.8849 mL | 3.7699 mL | 9.4247 mL | |
| 15 mM | 0.2513 mL | 1.2566 mL | 2.5133 mL | 6.2831 mL | |
| 20 mM | 0.1885 mL | 0.9425 mL | 1.8849 mL | 4.7124 mL | |
| 25 mM | 0.1508 mL | 0.7540 mL | 1.5080 mL | 3.7699 mL | |
| 30 mM | 0.1257 mL | 0.6283 mL | 1.2566 mL | 3.1416 mL | |
| 40 mM | 0.0942 mL | 0.4712 mL | 0.9425 mL | 2.3562 mL |
Aristolactam A II Related Classifications
HY-N2891 Related Classifications
Powered by Bioz