Antiplasmodial alkaloids from Desmos rostrata

  • J Nat Prod. 2008 Dec;71(12):2057-9. doi: 10.1021/np8004437.
Ngoc Tuan Nguyen  1 ,  Van Cuong Pham ,  Marc Litaudon ,  Françoise Guéritte ,  Philippe Grellier ,  Van Tuyen Nguyen ,  Van Hung Nguyen
Affiliations
  • 1. Institute of Chemistry, VAST, 18 Hoang Quoc Viet Road, Caugiay, Hanoi.
PMID: 19053513 DOI: 10.1021/np8004437
Abstract

Two new Alkaloids, desmorostratine (1) and discretine N-oxide (2), were isolated from the stem bark of Desmos rostrata, together with five known Alkaloids, discretine (3), dehydrodiscretine (4), pseudocolumbamine (5), predicentrine (6), and aristolactam AII (7). The structures were established on the basis of spectroscopic data, including mass spectrometry and 2D-NMR. Compound 1 was cytotoxic against KB cells (IC(50) 2.4 microM), while 2, 3, and 4 inhibited Plasmodium falciparum (IC(50) of 4.2, 1.6, and 0.9 microM, respectively).