53948-07-5
Chemical Structure
Aristolactam A II
Synonym(s): Aristololactam A II
- CAS No.: 53948-07-5
- Formula:C16H11NO3
- Molecular Weight:265.26
IUPAC Name: 2-hydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-one
InChIKey: ZEKAIRFOYPDZNC-UHFFFAOYSA-N
SMILES: O=C1NC2=C3C1=CC(O)=C(OC)C3=C4C(C=CC=C4)=C2
Biological Activity: Aristolactam A II (Aristololactam A II) is a weak COX inhibitor with cytotoxic and anti-plasmodial activities. Aristolactam A II exhibits inhibitory activity against Chloroquine (HY-17589A)-sensitive strains, and exerts its inhibitory effect on Plasmodium falciparum growth by inducing cell membrane damage marked by LDH release. Aristolactam A II can be applied to the research of malaria-related mechanisms[1][2][3].
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Aristolactam A II | 96.74% | Aristolactam A II (Aristololactam A II) is a weak COX inhibitor with cytotoxic and anti-plasmodial activities. Aristolactam A II exhibits inhibitory activity against Chloroquine (HY-17589A)-sensitive strains, and exerts its inhibitory effect on Plasmodium falciparum growth by inducing cell membrane damage marked by LDH release. Aristolactam A II can be applied to the research of malaria-related mechanisms. | ||||||||||||||||||||
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- [1]. Levrier C, et al. Pyridocoumarin, aristolactam and aporphine alkaloids from the Australian rainforest plant Goniothalamus australis. Phytochemistry. 2013;86:121-126. [Content Brief]
- [2]. Wei A, et al. Study on the contents of aristololactams in Piper wallichii and their renal cytotoxicitie
- [3]. Pröbstle A, et al. Aristolactams and a 4, 5-dioxoaporphine derivative from Houttuynia cordata[J]. Planta medica, 1992, 58(06): 568-569.
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