MMV019662 TFA

Cat. No.: HY-164686A: Data Sheet Handling Instructions
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MMV019662 TFA is a PfNCR1 inhibitor and antimalarial agent. MMV019662 TFA reduces gametocytemia levels of Plasmodium falciparum. MMV019662 TFA is applicable to malaria-related research.

For research use only. We do not sell to patients.

MMV019662 TFA Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

MMV019662 TFA is a PfNCR1 inhibitor and antimalarial agent. MMV019662 TFA reduces gametocytemia levels of Plasmodium falciparum. MMV019662 TFA is applicable to malaria-related research^[1]^[2].

IC₅₀ & Target^[1]

Plasmodium

In Vitro

MMV019662 (3× EC₉₀; 13 days) significantly reduces the total gametocytaemia level of blood-stage gametocytes of Plasmodium falciparum^[1].
MMV019662 (72 h) TFA inhibits the growth of the asexual erythrocytic stage of P. falciparum (Plasmodium falciparum) with an EC₅₀ of 1.18 μM^[1].
MMV019662 (0-100 μM) TFA does not thermostabilize purified PfNCR1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

579.61

Formula

C₂₉H₃₆F₃N₃O₆

Appearance

Solid

SMILES

O=C(C1CCCCC1)NCC(N2CCN(CC2)C3=CC=C(C=C3)OC)C4=CC=C5OCOC5=C4.FC(F)(C(O)=O)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kohling A, et al. Targeting ligand binding sites in Plasmodium falciparum NCR1 enables antimalarial drug discovery. bioRxiv, 2025: 2025.11. 11.687791.

[2]. Zhang Z, et al. The Plasmodium falciparum NCR1 membrane protein is a novel antimalarial target that exports cholesterol to maintain membrane homeostasis. bioRxiv, 2024: 2024.09. 30.615907.

MMV019662 TFA Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMV019662MMV 019662MMV-019662Parasitetryptophan fluorescence quenchingsexual blood stagesPfNCR1Plasmodium falciparumgametocytemiaMD simulationsgametocytogenesissterol-sensing domainasexual blood stageSSDInhibitorinhibitorinhibit

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