Chondroitin sulfate A disodium

Chondroitin sulfate A disodium serves as a stable/targeting ligand. Na₂SeO₃ is used to reduce and prepare nano-selenium particles (CSA-SeNP). These nanoparticles activate autophagy through the SIRT1-AMPK-FOXO3 pathway, thereby protecting chondrocytes from the oxidative stress and mitochondrial dysfunction caused by T-2 toxin^[1].
Chondroitin sulfate A disodium shows significantly higher expression in the epithelial component and stroma of solid/multicystic ameloblastoma than in odontogenic keratocyst or dentigerous cyst, with significantly stronger expression in stellate reticulum-like cells than in ameloblast-like cells within ameloblastoma^[2].
Chondroitin sulfate A (1-10 μg/mL; 1 h) disodium potently inhibits and reverses cytoadherence of Plasmodium falciparum FAF-EA8CHO5-infected erythrocytes to wild-type (K1) CHO cells, with 99.2% inhibition at 10 μg/mL and 72.5% inhibition at 1 μg/mL^[3].
Chondroitin sulfate A (1 h) disodium inhibits cytoadherence of Plasmodium falciparum FAF-EA8CHO5-, E10CHO6-, and D7CHO6-infected erythrocytes to C32 amelanotic melanoma cells, with 96.3% inhibition observed for FAF-EA8CHO5^[3].
Chondroitin sulfate A (1-10 μg/mL; 1 h) disodium almost completely inhibits cytoadherence of Plasmodium falciparum laboratory strains, selected high-binding strains, and primary patient isolates to immobilized chondroitin sulfate A-phosphatidylethanolamine^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.