2. Metabolic Enzyme/Protease Anti-infection Stem Cell/Wnt PI3K/Akt/mTOR
  3. Ser/Thr Kinase Parasite GSK-3
  4. PfGSK3/PfPK6-IN-1

PfGSK3/PfPK6-IN-1 is a dual Plasmodium serine/threonine kinase inhibitor, with an IC50 of 97 nM against PfGSK3 and 8 nM against PfPK6 of Plasmodium falciparum. PfGSK3/PfPK6-IN-1 inhibits the proliferation of blood-stage parasites of Plasmodium falciparum 3D7. PfGSK3/PfPK6-IN-1 shows low cytotoxicity to hepatocytes at a concentration of 200 nM, and reduces cell viability at a concentration of 2 μM. PfGSK3/PfPK6-IN-1 is applicable to malaria-related research.

For research use only. We do not sell to patients.

PfGSK3/PfPK6-IN-1

PfGSK3/PfPK6-IN-1 Chemical Structure

CAS No. : 2797225-49-9

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Based on 1 publication(s) in Google Scholar

PfGSK3/PfPK6-IN-1 Related Antibodies

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GSK-3 GSK-3α GSK-3β

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Description

PfGSK3/PfPK6-IN-1 is a dual Plasmodium serine/threonine kinase inhibitor, with an IC50 of 97 nM against PfGSK3 and 8 nM against PfPK6 of Plasmodium falciparum. PfGSK3/PfPK6-IN-1 inhibits the proliferation of blood-stage parasites of Plasmodium falciparum 3D7. PfGSK3/PfPK6-IN-1 shows low cytotoxicity to hepatocytes at a concentration of 200 nM, and reduces cell viability at a concentration of 2 μM. PfGSK3/PfPK6-IN-1 is applicable to malaria-related research[1].

In Vitro

PfGSK3/PfPK6-IN-1 (compound 23e) (0-5 μM; 72 h) inhibits the growth of Plasmodium falciparum 3D7 blood-stage parasites in vitro, with an EC50 value of 1400 nM[1].
PfGSK3/PfPK6-IN-1 (200 nM-2 μM; 48 h) exhibits certain cytotoxicity against HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PfGSK3/PfPK6-IN-1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HepG2
Concentration: 200 nM; 2 μM
Incubation Time: 48 h
Result: Resulted in 102% cell viability at 200 nM.
Resulted in 65% cell viability at 2 μM.
Molecular Weight

492.42

Formula

C22H23Cl2N5O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NCCCN1CCOCC1)C2=CC=C(NC3=NC=C(Cl)C(C4=CC=C(Cl)S4)=N3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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PfGSK3/PfPK6-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PfGSK3/PfPK6-IN-12797225-49-9Ser/Thr KinaseParasiteGSK-3Protein Serine-Threonine KinaseGlycogen synthase kinase-3Glycogen synthase kinase 3HepG2 cellshuman kinase targetsPfGSK3liver cellsrecombinant PfGSK3PfPK6Inhibitorinhibitorinhibit

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