2797225-49-9
Chemical Structure
PfGSK3/PfPK6-IN-1
- CAS No.: 2797225-49-9
- Formula:C22H23Cl2N5O2S
- Molecular Weight:492.42
IUPAC Name: 3-amino-1,2,4-oxadiazole-5-carbonitrile
InChIKey: FCGZLWCVWFYUTA-UHFFFAOYSA-N
SMILES: O=C(NCCCN1CCOCC1)C2=CC=C(NC3=NC=C(Cl)C(C4=CC=C(Cl)S4)=N3)C=C2
Biological Activity: PfGSK3/PfPK6-IN-1 is a dual Plasmodium serine/threonine kinase inhibitor, with an IC50 of 97 nM against PfGSK3 and 8 nM against PfPK6 of Plasmodium falciparum. PfGSK3/PfPK6-IN-1 inhibits the proliferation of blood-stage parasites of Plasmodium falciparum 3D7. PfGSK3/PfPK6-IN-1 shows low cytotoxicity to hepatocytes at a concentration of 200 nM, and reduces cell viability at a concentration of 2 μM. PfGSK3/PfPK6-IN-1 is applicable to malaria-related research[1].
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PfGSK3/PfPK6-IN-1 | 99.38% | PfGSK3/PfPK6-IN-1 is a dual Plasmodium serine/threonine kinase inhibitor, with an IC50 of 97 nM against PfGSK3 and 8 nM against PfPK6 of Plasmodium falciparum. PfGSK3/PfPK6-IN-1 inhibits the proliferation of blood-stage parasites of Plasmodium falciparum 3D7. PfGSK3/PfPK6-IN-1 shows low cytotoxicity to hepatocytes at a concentration of 200 nM, and reduces cell viability at a concentration of 2 μM. PfGSK3/PfPK6-IN-1 is applicable to malaria-related research. | ||||||||||||||||||||
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Keywords
