80938-69-8
Chemical Structure
DL-threo-PDMP hydrochloride
- CAS No.: 80938-69-8
- Formula:C23H39ClN2O3
- Molecular Weight:427.02
IUPAC Name: N-((1R,2R)-1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide hydrochloride
InChIKey: HVJHJOYQTSEKPK-BLDCTAJRSA-N
SMILES: O[C@H](C1=CC=CC=C1)[C@H](NC(CCCCCCCCC)=O)CN2CCOCC2.Cl
Biological Activity: DL-threo-PDMP hydrochloride is a competitive glucosylceramide synthase (GCS) inhibitor and antimalarial agent. DL-threo-PDMP hydrochloride competitively inhibits the activity of GCS. DL-threo-PDMP hydrochloride restores cisplatin sensitivity in cisplatin-resistant testicular germ cell tumor cells. DL-threo-PDMP hydrochloride blocks the growth of ring-stage Plasmodium falciparum parasites[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DL-threo-PDMP hydrochloride | 99.40% | DL-threo-PDMP hydrochloride is a competitive glucosylceramide synthase (GCS) inhibitor and antimalarial agent. DL-threo-PDMP hydrochloride competitively inhibits the activity of GCS. DL-threo-PDMP hydrochloride restores cisplatin sensitivity in cisplatin-resistant testicular germ cell tumor cells. DL-threo-PDMP hydrochloride blocks the growth of ring-stage Plasmodium falciparum parasites. | ||||||||||||||||||||
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References
- [1]. Piulats JM, et al. Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent. Clin Cancer Res. 2018;24(15):3755-3766. [Content Brief]
- [2]. Lauer SA, et al. Sphingolipid synthesis as a target for chemotherapy against malaria parasites. Proc Natl Acad Sci U S A. 1995;92(20):9181-9185. [Content Brief]
