2. Neuronal Signaling
  3. Glucosylceramide Synthase (GCS)
  4. D-threo-PPMP hydrochloride

D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production.

For research use only. We do not sell to patients.

D-threo-PPMP hydrochloride Chemical Structure

D-threo-PPMP hydrochloride Chemical Structure

CAS No. : 139889-65-9

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Based on 1 publication(s) in Google Scholar

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D-threo-PPMP hydrochloride Related Antibodies

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Description

D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP hydrochloride can block karyokinesis and reduce cyst production[1][2].

IC50 & Target

glucosylceramide synthase[1]
In Vitro

D-threo-PPMP (10 μM; 72 h) hydrochloride decreases the MDR1 expression by 70% in KB-V0.01 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-threo-PPMP hydrochloride Related Antibodies
Molecular Weight

511.18

Formula

C29H51ClN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@@H]([C@@H](C1=CC=CC=C1)O)CN2CCOCC2)CCCCCCCCCCCCCCC.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥98.0%

COA (243 KB)

Handling Instructions (2659 KB)
References
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D-threo-PPMP hydrochloride Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-threo-PPMP139889-65-9Glucosylceramide Synthase (GCS)glucosylceramideGlcCersynthasekaryokinesiscystInhibitorinhibitorinhibit

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